@article{Dr. Keshav Bansal_Dr. Dhaval Bhatt_Dr. Sunil Kumar Dadhich_Dr. Deep Kariya_2021, title={“Study of Estimation of Cerebrospinal Fluid C-Reactive Protein in Diagnosis of Acute Meningitis.”}, volume={8}, url={https://pediatrics.medresearch.in/index.php/ijpr/article/view/660}, DOI={10.17511/ijpr.2021.i04.02}, abstractNote={<p>Objectives: To assess the diagnostic role of CSF C-reactive protein quantitatively in acute meningitis and to evaluate the efficacy of CSF C-reactive protein in differentiating pyogenic meningitis from non-pyogenic meningitis.</p> <p>Material and Methods: It is a prospective observational study of total 102 children with suspected meningitis allocated into three groups based on initial investigations; group-I Pyogenic meningitis, group-II Non-Pyogenic meningitis and group-III No meningitis (Control group). Quantitative CSF C-reactive protein was detected by the latex agglutination method. Data were analyzed to establish the diagnostic role of CSF-CRP and to evaluate the efficacy of CSF-CRP in differentiating pyogenic meningitis from non-pyogenic meningitis.</p> <p>Results: A total of 102 clinically suspected meningitis patients were studied. Based on CSF findings, the study population (102 cases) was categorized into 3 groups. Group I was pyogenic meningitis consist 53 cases (51.96%). Group II was Non-Pyogenic meningitis consists 27 cases (26.47%). Group III was normal CSF findings consist 22 (21.56%). 98.1% cases of pyogenic meningitis had elevated CSF-CRP level &gt;1.1 µg/ml of CSF. In the case of Non-Pyogenic meningitis, 96.2% were found to have CSF- CRP in the range of 0.05-0.10 µg/ml. The mean value of CSF-CRP in groups I, II and III were 5.57±1.48,0.09±0.042 and 0.01±0.010 respectively.</p> <p>Conclusion: Detection of CSF-CRP provides a new dimension to establish the diagnosis of pyogenic meningitis. It is a rapid, reliable and sensitive diagnostic test. From this study it is concluded that CSF-CRP can be used to differentiate pyogenic from non-pyogenic meningitis. Early, accurate and appropriate therapy can ameliorate the morbidity and mortality rates in such cases.</p&gt;}, number={4}, journal={Pediatric Review: International Journal of Pediatric Research}, author={Dr. Keshav Bansal and Dr. Dhaval Bhatt and Dr. Sunil Kumar Dadhich and Dr. Deep Kariya}, year={2021}, month={Aug.}, pages={175-181} }