Pediatric Review: International Journal of Pediatric Research 2021-07-10T11:44:55+0530 Dr D Sharad Gedam Open Journal Systems <p><em><strong>ISSN: <a href="" target="_blank" rel="noopener">2349-3267 (Online)</a>, <a href="" target="_blank" rel="noopener">2349-5499 (Print)</a></strong></em></p> Clinical biochemical and serological profile in Children with Celiac disease 2021-06-30T14:05:55+0530 Dr. Vishal Shrivastava Dr. Purnendu Shekhar Lohia <p>Background: Celiac disease (CD) is a chronic, immunologically determined form of enteropathy affecting the small intestine, precipitated by the ingestion of gluten-containing foods such as wheat rye, barley etc. This study was taken up to analyze clinical manifestations and biochemical profile of children with celiac disease presenting at KEM Hospital Pune.</p> <p>Methods: All children diagnosed as CD in last 5 years and newly diagnosed patients of celiac satisfying inclusion criteria for next 1 year. This is an observational descriptive prospective and retrospective study. CD was diagnosed based on positive tTGA &amp; duodenal biopsy in children with chronic diarrhea &amp; other suggestive features. Hospital records were reviewed for complete follow up data.</p> <p>Results: In a study period of 12 months we diagnosed 19 children with Celiac Disease, who were studied prospectively, whereas 31 patients who were diagnosed within the last 6 years &amp; were on regular follow up in OPD were studied retrospectively. In the total group of 50 patients in the age range of 1year to 15 years. The presenting clinical features of our group of patients were: chronic diarrhea (92 %), failure to thrive (86%), abdominal pain (34%), abdominal distention (26%), anorexia/vomiting (8%/ 20%), &amp; weight loss (8%). Rare features were fever, fatigue, blood in stools &amp; constipation. In our study anemia was seen in 76% of patients, 58% of prospective patients had low ferritin levels.</p> <p>Conclusions: In a study period of 12 months we diagnosed 19 children with Celiac disease which goes to go prove that Celiac Disease, is not rare in western Maharashtra. Most patients belonged to the age group 1-5 years (50%) and the majority of patients were females (56%). Chronic diarrhea was the most common presenting complaint in all age groups ( 92%) followed by failure to thrive, not gaining weight and abdominal pain. Constipation was least common. Anemia was the most common laboratory-confirmed finding and the most common type of anemia was iron deficiency anemia. Prevalence Anemia was most common in below 5 yrs.</p> 2021-06-15T13:14:27+0530 Copyright (c) 2021 Author (s). Published by Siddharth Health Research and Social Welfare Society The early indicator of significant hyperbilirubinemia in healthy full-term infants at 72 hrs of age: A prospective cohort study 2021-07-09T16:03:47+0530 Sunil Arys Jyoti Prajapati Chetan Panwar <p>Introduction Hyperbilirubinaemia is a very common and frequently benign condition in newborns, but is a leading cause of hospitalisation in the first week of life. Many healthy full-term newborns develop significant hyperbilirubinemia, often leading to serious complications as bilirubin encephalopathy and death. The present study was aimed to determine early predators and risk factors in full-term healthy newborns developing significant hyperbilirubinemia.</p> <p>Methods - This was a prospective observa-tional cohort study conducted at the department of pediatrics at a tertiary care teaching hospital over 1 year enrolling 200 full-term healthy newborns and following them from birth to 72 hrs of life to determine early predictors of hyperbilirubinemia. The data were analysed using the Statistical Package of Social Science Software (SPSS) program. Bilirubin levels measured at 72 hrs were compared to identify significant hyperbilirubinemia using cut off at or above high intermediate risk zone in Bhutani nom-ogram.</p> <p>Results- Neonates with birth weight &lt;2.5 kg, born through instrumental delivery, delayed feeding, dehydration, 24 Hr serum bilirubin &gt;6mg/dl and 48 Hr serum bilirubin &gt;11 mg/dl were significantly associated with significant hyperbilirubinemia( p&lt;0.05)</p> <p>Conclusion- These risk factors can be used as risk indicator to predict the development of significant hyperbiliru-binemia in such newborns and better pre-discharge counselling and followup can be ensured in such newborns especially in re-source-limited settings.</p> 2021-06-30T00:00:00+0530 Copyright (c) 2021 Author (s). Published by Siddharth Health Research and Social Welfare Society Knowledge, attitudes and practices regarding infant feeding among mothers of children with severe acute malnutrition in the rural areas of Northern India 2021-07-09T19:58:48+0530 Dr. Divya Verma Dr. Sunil Kumar Singh <p>Introduction: Malnutrition has been identified as one of the principal causes limiting India’s global economic potential. The infant and young child-feeding practices determine the nutritional status, growth and ultimately the survival of infants and young children. The study aimed to assess the knowledge, attitude and practices of rural mothers with children diagnosed with severe acute malnutrition (SAM) regarding infant feeding.</p> <p>Methodology: A hospital-based cross-sectional descriptive study on 116 mothers from the rural area of Northern India with children diagnosed with SAM. Assessment of knowledge, attitude and practice of mothers regarding infant feeding was done through face to face interviews using a structured questionnaire containing 32 questions.</p> <p>Results: The mean age of admitted children was 14.48 ± 4.71 months. The majority of mothers (81.9%) studied till only primary school or were illiterate. The appropriate knowledge about early initiation of breastfeeding and the ideal time to start complementary feeding was found in 42.4% and 45.6% of mothers respectively which was suboptimal. The attitude towards ideal breastfeeding practices was positive in most mothers. However in practice only 59.4% of mothers exclusively breastfed their babies till 6 months and 54.3% delayed initiation of complementary feed beyond 9 months of age. The frequency of complementary feeding was inadequate in the 6-8 months age group as stated by 88.6% of mothers and minimum dietary diversity was not followed by 68.1% of mothers.</p> <p>Conclusion: The knowledge and positive attitude towards infant feeding are not applied in practice by mothers. Efforts should be made to improve knowledge, attitude and practice with an emphasis on complementary feeding indicators to reduce the burden of malnutrition in the rural population.</p> 2021-06-30T00:00:00+0530 Copyright (c) 2021 Author (s). Published by Siddharth Health Research and Social Welfare Society To study the correlation between various levels of cord blood albumin & serum bilirubin at 48 hrs of age in term healthy newborns 2021-07-10T11:44:55+0530 Sunil Arya Chetan Panwar Jyoti Prajapati <p>Introduction: Neonatal Hyperbilirubinemia is the most common abnormal physical finding and the major cause of neonatal morbidity during the early neonatal period. Early identification of infants at risk might help in providing preventative therapy and follow-up. We aimed to assess whether arterial umbilical cord albumin level at birth predicts the development of neonatal hyperbilirubinemia in term newborns at 48 hrs of life.</p> <p>Methods: This prospective observational cohort study was conducted in a tertiary care hospital over 1 year in 200 term healthy neonates. Cord blood albumin was estimated at birth followed by serum bilirubin level on the 3rd postnatal day(48 hrs of age).</p> <p>Results: Total of 200 neonates were divided into three groups based on cord blood albumin level of &lt;2.8 g/dl(group I), 2.8-3.4 g/dl(group II) and &gt;3.4 g/dl(groupIII) with 32, 100 and 68 in three respective groups. 19 newborns (59.4%) in group I,14 in group II, and 7 newborns (10.3%) in group III developed serum bilirubin levels above an intermediate high-risk zone in Bhutani nomogram at 48 hrs of age. newborn with low cord albumin (&lt;2.8g/dl) were significantly associated with higher bilirubin levels at 48 hrs of age.</p> <p>Conclusion: Neonates with cord blood albumin &lt;2.8 gm/dl had a significant association of the development of hyperbilirubinemia at or above intermediate high-risk zone according to Bhutani nomogram at 48 hrs of life.</p> 2021-07-10T11:31:25+0530 Copyright (c) 2021 Author (s). Published by Siddharth Health Research and Social Welfare Society