Pediatric Review: International Journal of Pediatric Research 2020-07-10T05:40:06+00:00 Dr Ram Gopal Verma, MOB: +91-9977225727 (Mon-Sat) Open Journal Systems <p><em><strong>ISSN: 2349-3267 (Online), 2349-5499 (Print),&nbsp;<span style="text-decoration: underline;">Monthly</span>, Indexed with Index Copernicus</strong></em></p> <p>Pediatric Review: International Journal of Pediatric Research (IJOPR) is commencing its publication from May 2014. It is a speciality, peer reviewed open access medical Journal. It is publishing Monthly from January 2016 onward</p> <p>It full fill all criteria updated in Sepember 2015 for promotion by MCI {Medical Council of India}. It is Indexed with Index Copernicus. <a title="IC Link" href="" target="_blank" rel="noopener">Link</a><br><br>Pediatric Review: International Journal of Pediatric Research (IJOPR) is published by Siddharth Health Research and social welfare society which is registered under MP Society registration act, 1973.<br><br>Link for society Registration. <a title="Registration" href="" target="_blank" rel="noopener">Link1:</a><br><br>This is an open access journal which means that all content is freely available without any charges to the user or his/her institution. Users are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles in this journal without asking prior permission from the publisher or the author. This is in accordance with the BOAI definition of open access.<br><br>We welcome articles from all medical specialties related with Pediatrics like Pediatric Medicine, Pediatric Surgery, Neonatology and other Pediatrics sub specialities. We accept, in English Review articles, Research/Original articles, Case Reports, Case series, Research letters &amp; Letters to Editor.<br><br>Our motto to is to provide an international platform to the large volume of research work which in going on all around the world. Our mission is to update medical fraternity with the latest knowledge. We are committed and promise to take this journal to greaterer heights. We request all readers to submit articles for the upcoming issue.<br><br>We are already indexed with Index Copernicus, Google Scholar, Cross reference, Research Boble, etc. We are making efforts to get indexed with other International and National databases shortly.</p> Clinical profile of pediatric patients with cerebral palsy 2020-07-09T04:35:59+00:00 Saroj Sanjeev Gupta Pranav Sanjeev Gupta <p>Background and Aim: Cerebral Palsy (CP) describes a group of permanent disorders of the development of movement and posture, causing activity limitation, that is attributed to nonprogressive disturbances that occurred in the developing fetal or infant brain. Hence the present study was planned with the sole objective to study the clinical profile of patients of cerebral palsy and to assess the spectrum of functional disability.</p> <p>Materials and Methods: A total of 100 consecutive children diagnosed as cerebral palsy attending the pediatric department and Rehabilitation center were included in the study. Participants were examined forbehavioral problems like Pervasive Developmental Disorders (PDD) and ADHD. Complete evaluation of a child with CP included an assessment of associated deficits like vision, speech and hearing, oromotor evaluation, epilepsy, and cognitive functioning.</p> <p>Results:Out of 1000 cases studied, spastic cerebral palsy was the commonest physiological type of cerebral palsy (82%). atonic, athetoid, and dystonic types formed the rest of the 18% of cases. Among the spastic group, quadriplegia was the commonest topographical type (48%) followed by diplegia (24%). The study showed 96% of patients were mentally retarded. In the study, 48% ofchildren with CP had a seizure disorder.</p> <p>Conclusion: Spastic cerebral palsy was the commonest clinical type of cerebral palsy withquadriplegia being the most common topographical type of spastic cerebral palsyfollowed by diplegia as observed in this study. The prevalenceof behavioral problems like autism spectrum disorder and ADHD in the clinical sampleof children with CP was found to be 10%.PDD is not rare in CP and should be considered in patients with other comorbid conditions.</p> 2020-06-30T00:00:00+00:00 Copyright (c) 2020 Author (s). Published by Siddharth Health Research and Social Welfare Society Nutritional status characteristics of infants presenting with neonatal cholestasis 2020-07-09T04:40:28+00:00 Laxmi Kant Bharti Jai Kishun <p>Background:Neonatal cholestasis (NC) is one of the commonest presentations in early infancy diseases. The nutritional status of infants may be affected by many factors. Impaired bile flow may further lead to the nutritional compromise of infants. Timely nutritional assessment and adequate nutritional support in the form of adequate breastfeeding and if required appropriate formulae feeding according to age and weight is crucial for better outcomes in improving morbidity and decreasing mortality of infants with NC.</p> <p>Methods:Consecutive 143 patients of NC up to 12 months enrolled from the HIS data (hospital information system). Anthropometric examination, mode, and type of feeding and serum markers like LFT (liver function test) and Hb (hemoglobin) were recorded. Data were analyzed by IAP growth parameters and SPSS 21.</p> <p>Results:The mean age of NC presentation was 3.6 months. 74(51.7%) were on mixed feeding, 61(42.6%) were exclusively breastfed (EBF) and only 8(5.6%) infants were on only top feeding by formula feeding or bovine milk feed. 39.16% were undernourished and around 19.5% were stunted.40% infants were anemic. The median value of serum albumin in top-fed and EBF (exclusive breastfed) was low.</p> <p>Conclusions:Malnutrition is common in infants with NC. There area different feeding pattern and type observed in infants with NC. EHBA (extrahepatic biliary atresia) is the most common diagnosis in infants with NC presented to the tertiary care center. Early nutritional assessment and timely nutritional supplementation having a crucial role in the outcome of patients with various diagnoses in NC.</p> 2020-06-30T00:00:00+00:00 Copyright (c) 2020 Author (s). Published by Siddharth Health Research and Social Welfare Society Study of glycemic status, thyroid function and vitamin D3 level in children with β thalassemia major in a tertiary care center 2020-07-10T03:34:05+00:00 Dhiraj Kumar Solanki Shashikant Dewangan Bhoopendra Sahu <p>Introduction: β thalassemia has emerged as a huge public health problem worldwide. Thyroxine reserve is reduced in multitransfused thalassemia patientsanddiabetes can also be a considerable complication.Vitamin D3 deficiency is noted in thalassemia patients and is related to bone diseases.</p> <p>Aims and Objectives: Study of glycemicstatus, thyroid function, and vitamin D3 level in children with βthalassemia major.</p> <p>Method:Socio-demographic information wascollected by using the pretested and predesigned structured pro forma by interview technique. HbA1c level, vitamin D3 level,and thyroid function had been obtained from the lab.</p> <p>Result:In 89% of subjects TSH levels were normal with a mean value of 5.04.In 10.9%it was increased witha mean value of TSH being 6.67.VitaminD3 level in 2% children was below 20ng/ml, 50.50% had between 21 to 29ng/ml and 47.52% had between 30-60 ng/ml. Vitamin D3 deficiency increased with a higher blood transfusion rate (p-value 0.000). In 88.12%of the study, subjectsHbA1c was normal, 11.18%were inthe pre-diabetic range,and none of the subjects were diabetic as per HbA1C results. The mean value of HbA1C in normal children was 4.79%whereas in prediabetic children mean value of HbA1C was 6.13%.</p> <p>Conclusion: In the present study multiple endocrine abnormalities were common in multi transfused thalassemia major patients. Prevalence of subclinical hypothyroidism and prediabetes increased with a higher blood transfusion rate and higher serum ferritin level. Prevalence of subclinical hypothyroidism and prediabetes increased with age (p-value &lt;0.05).</p> 2020-06-30T00:00:00+00:00 Copyright (c) 2020 Author (s). Published by Siddharth Health Research and Social Welfare Society Transfusion practices in the pediatric and neonatology departments of Soavinandriana hospital center 2020-07-09T04:51:20+00:00 Rosa Lalao Tsifiregna Mbola Rakotomahefa Narison Filaminantsoa Nambininjanahary Annick Lalaina Robinson Olivat Rakoto Alison <p>Blood transfusion is an important part of day-to-day clinical practice. The main objective of this work is to describe transfusion practices in the Pediatrics and Neonatology Department of the Hospital Center of Soavinandriana.</p> <p>Methods: A prospective observational study of 6 months has been conducted. All requests to Department of Pediatrics and Neonatology for blood for transfusion for children aged less than 14 years were identified prospectively. The variables studied were: patients’ characteristics (age, gender) reason for hospitalization, paraclinical examinations (blood count and formula before transfusion, ABO and Rhesus grouping), the presented pathology, the indicated transfusion: nature, incidents during and after transfusion and the outcome of the pathology (healing, death).</p> <p>Results: The incidence was 6.54%, 33 patients had a blood transfusion. The sex ratio was 1.35. The average age is 46.06 months. Skin pallor was the main reason for hospitalization, which represented 18.18% of the cases. The average hemoglobin level was 8.08 g/dl. The O and rhesus positive blood group was the predominant in this work. The blood products which were used were: red blood cell (n=20, 54.05%), whole blood (n=15, 40.54%), fresh frozen plasma (n=1, 2.70%), platelets concentrate (n=1, 2.70%). The National Center for Blood Transfusion of the Joseph Ravoahangy Andrianavalona University Hospital Center had delivered the vast majority of the used blood bags.</p> <p>Conclusion: The packed red blood cell was used the most and the hospital blood bank did not have enough labile blood products. It is therefore essential to improve the structures for the preparation of blood and its derivatives, in order to make all varieties of labile blood products accessible.</p> 2020-06-30T00:00:00+00:00 Copyright (c) 2020 Author (s). Published by Siddharth Health Research and Social Welfare Society Krabbe disease - a rare lysosomal storage disease 2020-07-10T05:40:06+00:00 Vijay Baburao Sonawane V.A. Kotrashetti Kapil S Bainade Amit Vatkar Shuchi R Bhatarkar <p>Krabbe disease a rare and fatal lysosomal storage disease that results in progressive damage, demyelination of central, and peripheral nervous system. It involves the dysfunctional metabolism of sphingolipids; characterized by the deficiency of enzyme galactocerebrosidase (galactosylceramidase, GALC). Krabbe disease is an extremely rare condition with an incidence of 1 in 1,00,000 live births. Typically, the disease has an infantile-onset, with rapid deterioration in the first few months, leading to death before the age of 2 years. The late-onset forms (late-infantile, juvenile, and adult forms) are rare with variable clinical outcomes, presenting spastic paraplegia as the main symptom. It is inherited in an autosomal recessive pattern. Early diagnosis of Krabbe disease can be made by measuring the activity of galactocerebrosidase in a sample of a dried spot of blood during the screening of new-born infants. Radiological investigations can show diffuse brain and cerebellar atrophy, and demyelination can be identified by magnetic resonance imaging (MRI). Authors report a case of a 10-year-old female child presented with feeding difficulties excessive irritability, global developmental delay, and progressive loss of hearing and sight. On examination had peculiar facial features, hypertonia, and hyper reflexes. No neurocutaneous stigmata were found. Diagnosed as Krabbe's disease on the basis of peculiar clinical features and confirmed diagnosis on MRI and spectrophotometric and spectrofluorometric enzyme assay. There's no cure for Krabbe disease, and treatment focuses on supportive care. However, stem cell transplants have shown some success in infants who are treated before the onset of symptoms and in some older children and adults.</p> 2020-06-30T00:00:00+00:00 Copyright (c) 2020 Author (s). Published by Siddharth Health Research and Social Welfare Society