A rare case of Loperamide toxicity in a neonate

  • Dr Venkatmurthy M Adichunchangiri Institute of Medical Sciences, Bengaluru - Mangaluru Hwy, Karnataka 571418, India
  • Dr Balaji M D Adichunchangiri Institute of Medical Sciences, Bengaluru - Mangaluru Hwy, Karnataka 571418, India
  • Dr Sneha M Adichunchangiri Institute of Medical Sciences, Bengaluru - Mangaluru Hwy, Karnataka 571418, India
Keywords: Toxicity, CNS depression, Loperamide, Naloxone

Abstract

loperamide hydrochloride is indicated for the control and symptomatic relief of acute nonspecific diarrhea and of chronic diarrhea associated with inflammatory bowel disease. Its use in paediatric age group less than 12 years is not recommended. Toxicity with therapeutic dose has been reported to cause urinary retention, paralytic ileus, respiratory depression due to CNS depression in infants and toddlers.

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References

1. Sandhu BK, Tripp JH, Candy DC, Harries JT. Loperamide: studies on its mechanism of action. Gut. 1981 Aug;22(8):658-62. [PubMed]

2. Upton RN. Cerebral uptake of drugs in humans. Clin Exp Pharmacol Physiol. 2007 Aug;34(8):695-701. [PubMed]

3. Tan SH. Loperamide toxicity in an infant. Aust Paediatr J. 1983 Mar;19(1):55. [PubMed]

4. Minton NA, Smith PG. Loperamide toxicity in a child after a single dose. Br Med J (Clin Res Ed). 1987 May 30;294(6584):1383. [PubMed]

5. Bhutta TI, Tahir KI. Loperamide poisoning in children. Lancet. 1990 Feb 10;335(8685):363. [PubMed]

6. Wood JD, Galligan JJ. Function of opioids in the enteric nervous system. Neurogastroenterol Motil. 2004 Oct;16 Suppl 2:17-28. [PubMed]

7. Li ST, Grossman DC, Cummings P. Loperamide therapy for acute diarrhea in children: systematic review and meta-analysis. PLoS Med. 2007 Mar 27;4(3):e98. [PubMed]

8. Friedli G, Haenggeli CA. Loperamide overdose managed by naloxone. Lancet. 1980 Jun 28;1(8183):1413. [PubMed]
A rare case of Loperamide toxicity in a neonate
CITATION
DOI: 10.17511/ijpr.2016.i07.14
Published: 2016-07-31
How to Cite
Dr Venkatmurthy M, Dr Balaji M D, & Dr Sneha M. (2016). A rare case of Loperamide toxicity in a neonate. Pediatric Review: International Journal of Pediatric Research, 3(7), 543-545. https://doi.org/10.17511/ijpr.2016.i07.14
Section
Case Report