Acute hepatic failure with encephalopathy in children
Abstract
Introduction: Hepatic encephalopathy is a serious and likely to be reversible neurophyschiatric state in the patient of liver failure. Acute hepatic failure is a life-threatening condition in children.
Objectives: The study analyses the clinical spectrum, prognosis and factors determining the prognosis of children with acute hepatic failure and associated encephalopathy in a tertiary level hospital.
Methodology: Thirty two children (18 males and 14 females) were presented with the diagnosis over a two year period. It is a Prospective study.
Results: The commonest cause of acute hepatic failure was hepatitis A virus found in 30% of cases. Only 30% (9 out of 32) children could be survived, in which mostly came in hepatic encephalopathy Stage I and II. Hemorrhagic manifestations were significantly more (P=0.002) in died in contrast to survived.
Conclusion: Hepatic failure is a condition associated with high mortality primarily in absence of hepatic transplantation facilities. Focus of efforts should be in providing preventive steps such as immunization and society education.
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References
2. Azoulay D, Castaing D, Adam R, Mimoz O, Bismuth H. Transplantation of three adult patients with one cadaveric graft: wait or innovate. Liver Transpl. 2000 Mar;6(2):239-40. [PubMed]
3. Ferenci P, Lockwood A, Mullen K, Tarter R, Weissenborn K, Blei AT. Hepatic encephalopathy--definition, nomenclature, diagnosis, and quantification: final report of the working party at the 11th World Congresses of Gastroenterology, Vienna, 1998. Hepatology. 2002 Mar;35(3):716-21.
4. Blei AT, Córdoba J; Practice Parameters Committee of the American College of Gastroenterology. Hepatic Encephalopathy. Am J Gastroenterol. 2001 Jul;96(7):1968-76. [PubMed]
5. Rehm J, Samokhvalov AV, Shield KD. Global burden of alcoholic liver diseases. J Hepatol. 2013 Jul;59(1):160-8. doi: 10.1016/j.jhep.2013.03.007. Epub 2013 Mar 16. [PubMed]
6. Dienstag JL. Non-A, non-B hepatitis. I. Recognition, epidemiology, and clinical features. Gastroenterology. 1983 Aug;85(2):439-62. [PubMed]
7. Health R, Services A, Centers for Disease Control and Prevention (CDC, HIV Medicine Association of the Infectious Diseases Society of America. Incorporating HIV prevention into the medical care of persons living with HIV. Recommendations of CDC, the Health Resources and Services Administration, the National Institutes of Health, and the HIV Medicine Association of the Infectious Diseases Society of America. MMWR. Recommendations and reports: Morbidity and mortality weekly report. Recommendations and reports/Centers for Disease Control. 2003 Jul 18;52(RR-12):1. [PubMed]
8. Liaw YF, Chu CM. Hepatitis B virus infection. Lancet. 2009 Feb 14;373(9663):582-92. doi: 10.1016/S0140-6736(09)60207-5. [PubMed]
9. Bernuau J, Rueff B, Benhamou JP. Fulminant and subfulminant liver failure: definitions and causes. Semin Liver Dis. 1986 May;6(2):97-106. [PubMed]
10. Dhawan A, Cheeseman P, Mieli-Vergani G. Approaches to acute liver failure in children. Pediatr Transplant. 2004 Dec;8(6):584-8. [PubMed]
11. Devictor D, Desplanques L, Debray D, Ozier Y, Dubousset AM, Valayer J, Houssin D, Bernard O, Huault G. Emergency liver transplantation for fulminant liver failure in infants and children. Hepatology. 1992 Nov;16(5):1156-62. [PubMed]
12. Williams R, Wendon J. Indications for orthotopic liver transplantation in fulminant liver failure. Hepatology. 1994 Jul;20(1 Pt 2):S5-10S. [PubMed]
Copyright (c) 2016 Author (s). Published by Siddharth Health Research and Social Welfare Society
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