Co existence of acute promyelocytic leukemia and autoimmune haemolytic anaemia in a girl – A diagnostic and therapeutic challenge
Keywords:
Promyelocytic leukemia, Autoimmune haemolytic anemia, Arsenic trioxide, All-trans- retinoic acid
Abstract
We describe a very rare case of paediatric female patient of acute promyelocytic leukemia (APL) with negative promyelocytic leukemia–retinoic acid receptor-α (PML- RARα) and normal karyotype co existing with autoimmune haemolytic anemia(AIHA) for the rarity, diagnostic and management challenges. The clinical outcome with arsenic trioxide (ATO) and all-trans- retinoic acid (ATRA) regime is good without relapse or residual disease with a close follow up of 6 months.
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2. Boccardi V, Papa G, Antonelli S, Girelli G, Liso V, Mandelli F. Autoimmune hemolytic anemia followed by myelomonocytic leukemia. Haematologica. 1977 Feb;62(1):88.
3. FRUMIN AM, KOHN A. Autoimmune hemolytic disease in acute leukemia. AMA archives of internal medicine. 1955 Feb 1;95(2):326-7.doi:10.1001/archinte.
4. PIROFSKY B. Autoimmune hemolytic anemia and neoplasia of the reticuloendothelium: with a hypothesis concerning etiologic relationships. Annals of internal medicine. 1968 Jan 1;68(1):109-21.doi:10.7326/0003-4819-68-1-109.
5. Solal‐Celigny P, Vazeux R, Vroclans M, Amar M, Herrera A, Bernard JF, Boivin P. Positive Coombs test in acute leukaemia. British journal of haematology. 1984 Aug 1;57(4):563-9. DOI: 10.1111/j.1365-2141.1984.tb02933.x [PubMed]
6. Nargund AR, Patil GV, Raghuram CP, Venkataswamy E. CD34 positive-microgranular variant of acute promyelocytic leukemia in a child. Indian Journal of Pathology and Microbiology. 2012 Oct 1;55(4):574. DOI: 10.4103/0377-4929.107828.
7. Yoo ES. Recent advances in the diagnosis and management of childhood acute promyelocytic leukemia. Korean J Pediatr. 2011 Mar;54(3):95-105. doi: 10.3345/kjp.2011.54.3.95. Epub 2011 Mar 31. [PubMed]
8. Chaudhary RK, Das SS. Autoimmune hemolytic anemia: From lab to bedside. Asian journal of transfusion science. 2014 Jan 1;8(1):5. DOI: 10.4103/0973-6247.126681. [PubMed]
9. Tamura H, Ogata K, Yokose N, et al.Autoimmune hemolytic anemia in patients with de novo acute myelocytic leukemia. Ann Hematol 1996;72:45-47. DOI: 10.1007/BF00663016. [PubMed]
10. Arbaje YM, Beltran G. Chronic myelogenous leukemia complicated by autoimmune hemolytic anemia. The American journal of medicine. 1990 Feb 28;88(2):197-9. [PubMed]
11. Ben-Ishay D, Freund M, Groen JJ. A case of autoimmune hemolytic anemia with circulating cold agglutinins presenting for many years as" hypersplenism" and terminating in leukemia. Blood. 1963 Jul 1;22(1):100-8.
CITATION
DOI: 10.17511/ijpr.2016.i08.15
Published: 2016-08-31
How to Cite
Dr Jerusha Samuela Jacob, Dr Febe Renjitha Suman, Dr Julius Xavier Scott, & Dr MS Latha. (2016). Co existence of acute promyelocytic leukemia and autoimmune haemolytic anaemia in a girl – A diagnostic and therapeutic challenge. Pediatric Review: International Journal of Pediatric Research, 3(8), 640-643. https://doi.org/10.17511/ijpr.2016.i08.15
Section
Case Report
Copyright (c) 2016 Author (s). Published by Siddharth Health Research and Social Welfare Society
This work is licensed under a Creative Commons Attribution 4.0 International License.
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