A study of evaluation of iron deficiency as a risk factor for febrile seizures
Abstract
Objective: To estimate the incidence of seizure of iron deficiency anemia in febrile seizure. To determine the clinical correlates of children with febrile seizures.
Methods: In this case, control study was conducted among 126 children of age group between 6 months and 5 years during April 2015 to April 2016. The control case groups were matched based on the family history of febrile seizure, age, sex, and temperature. Blood samples were collected. Measured quantities of serum feritin, hemoglobin, mean corpuscular volume and mean corpuscular hemoglobin were compared.
Result: 36 children (28.5%) in the febrile Seizure group have positive family history when compared to none among controls. Serum ferritin level in febrile seizure group is found to have 14.5+/-10.6 ng/ml, where as in controls it is 34.9+/-23.3 ng/ml .The mean hemoglobin was 9.8+/-1.2 gm/dl whereas in controls, it was 11.3+/-1.1gm/dl. The mean corpuscular volume is 76+/-8.5fl, whereas in control it is 79.5+/-7.5fl, which was statistically significant. The mean corpuscular hemoglobin was 27.7+/-3.1pg and for control it was 28.7/3.6 pg.
Conclusion: Serum ferritin, Hb% and MCV were found to be significant on the lower side in children with febrile seizure when compared to the children who did not have febrile seizure.
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References
2. Stoltzfus R. Defining iron Deficiency anemia in public health terms, a time for reflection .J Nutr. 2001; 13!565S-567S. [PubMed]
3. DeMaeyer E , Adiels-Tegman M. The prevalence of anemia in the world. World health state Q.1985;38:302-16. [PubMed]
4. Rantala H, Uhari M. Risk factor for recurrences of Febrile Convulsions. Acta Neurol Scand 1994:90:207-10. [PubMed]
5. Lozoff B, Georgieff M.K, Iron deficiency and brain development .Semin peditr Neurol.2006:13:158-65. [PubMed]
6. Van der Berg BJ, Yerushalmy J. Studies on convulsive disorders in young children. I. Incidence of febrile and nonfebrile convulsions by age and other factors. Pediatr Res. 1969 Jul;3(4):298-304.
7. Ling S G. Clinical characteristics and risk factors for a complex first febrile convulsion. Singapore Med J. 2001;42: 264-7. [PubMed]
8. Berg AT, Shinnar S, Darefsky AS et al. Predictors of recurrent febrile Seizurs. A prospective cohort study Arch pediatric Addex Med 1997; 151:371-8. [PubMed]
9. Rehman N, Billoo AG, ET Al .Association between iron deficiency and febrile Seizures. J.Coll. Physicians Surg.Pak. 2005;15(6)338-40. [PubMed]
10. Daoud AS, Batchia A, Al-Sheyyab M, Effectiveness of iron therapy on breath holding spells. J.Pediater 1997; 130:547-50. [PubMed]
11. Maliyar A, Rezac MA. Ferritin level in children with and without Febrile Convulsry. Journal of Karmanshah University of Medical Sciences . 2006; 10:2004.
12. Talebian A, Andalibs, Veji 2006; 10:2004.a Moravvaji SA, Vakiliz:Serum Ferrtin level in febrile children with or without Seizure. KAUMS Journal (FEY2)2011;15(H):389.93.
13. Vaswani RK, Dharaskar PG, Kulkarni S, Ghosh K. Iron deficiency as a risk factor for first febrile seizure. Indian Pediatr. 2010 May;47(5):437-9. Epub 2009 Sep 3. [PubMed]
14. Daoud AS, Batchia A, Abu Esctarsh F et al. Iron status .A possible risk factor for first febrile Seizure.Epilepsia 2002;43:740-3. [PubMed]
15. Pisacane A, Jansone P, Impaliazzo N et al. Iron deficiency anemia and febrile convulsion .Case control study in children under 2 years Brit Med J 1996; 313-343. [PubMed]
16. Lozoff B, Beard J, connor J, Felt B, Georgieff M, and Schallert T. Long –lasting neural and behavioral effect of iron deficiency in infancy. Nutr Rev. 2006;64:S34-91. [PubMed]
17. Wigglesworth J.M, Baum H. Iron dependentenzymes in the brain , In: M.B.H. youdim(Ed). Brain iron in neurochemical and behavioral aspects. Taylor. Taylor and Francis, New York, NY; 1988:25-66. [PubMed]
18. Akihisa O, Yoshiko I , Ayako S., Koichi M, Tet sou K et al. Treatment and out come in patients with febrile convulsion associated with Epileptiform discharges on electro enephalography. Brain Dev.2004;26:241-4. [PubMed]
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