Relationship between ABO blood group system and falciparum malaria in paediatric age group
Abstract
Background: The associations of ABO blood group with different diseases were being reported from time to time. Recent works from different parts of the world have shown that O blood group is less prone and AB and B group is more prone to developed severe falciparum malaria than other blood group.
Objective: To study if there is any association existing between ABO blood group and severe falciparum malaria.
Methods: This was tertiary case control study which included 309 cases of diagnosed falciparum malaria paediatric cases. 163 health controls were screened for ABO blood group. Clinical manifestations of the patients were recorded and classified as severe / complicated according to the WHO criteria. Statistical analysis was done to find out the P value and odds ratio.
Result: Frequency of severity in ‘O’ blood group patients was lower in comparison to the severity in A and B blood group. Blood group B was significantly associated with severity when compared with uncomplicated (P<0.05, OR=0.56) and healthy controls (P<0.05, OR=0.56) of the group B. prevalence of O group in uncomplicated (P<0.001, OR=13.32) and healthy controls (P<0.005, OR=0.50) was significantly high compared to severe malaria of O group.
Conclusion: This study shows the relative immunity of O group for the severity of falciparum malaria and relative high propensity of B blood group for the severity of falciparum malaria in the pediatric age group.
Downloads
References
2. Frattali A and spitalnik SL. Blood Group Antigens as Receptors for Pathogens. In Blancher A, Klein J, Socha WW (Eds.). Molecular Biology and Evolution of Blood group and MHC Antigens in Primates 1997; Heidelberg Springer PP. 268-304. [PubMed]
3. Aird I, Bentall HhH, Roberts JaA. A relationship between cancer of the stomach and the ABO blood groupsBr Med J. 1953 Apr 11;1(4814):799-801. [PubMed]
4. Lell B, May J, Schmidt – Ott RJ, et al. The role of red blood cell polymorphisms in resistance and susceptibility to malaria. Clin Infect Dis. 1999 Apr;28(4):794-9. [PubMed]
5. Pathirana SL. Alles HK, Bandara S, et al. ABO blood group types and protection against severe plasmodium falciparum malaria. Ann Trop Med Parasitol 2005; 99 : 119-124. [PubMed]
6. Fischer PR and Boone P. Short report : Severe malaria associated with blood group. Am J Trop Med Hyg. 1998 Jan;58(1):122-3. [PubMed]
7. Loscertales M-P, Brabin BJ. ABO phenotypes and malaria related outcomes in mothers and babies in the Gambia : a role for histo – blood groups in placental malaria ? Malaria J 2006; 5 : 1-6. [PubMed]
8. Panda AK, Panda Santosh K, Sahu AN et al. Association of ABO blood goup with severe falciparum malaria in adults : case control study and meta-analysis. Malar J. 2011 Oct 19;10:309. doi: 10.1186/1475-2875-10-309.
9. Cserti cm, Dzik WH. The ABO blood group system and plasmodium falciparum malaria. Blood. 2007 Oct 1;110(7):2250-8. Epub 2007 May 14. [PubMed]
10. World Health Organization Severe falciparum malaria. World Health Organization, Communicable Diseases Cluster. Trans R. Soc Trap Med. Hyg.2000; 94 : 1-90.
Copyright (c) 2016 Author (s). Published by Siddharth Health Research and Social Welfare Society
This work is licensed under a Creative Commons Attribution 4.0 International License.