A study of effect of gestational diabetes on the newborn

  • Dr. Rajith. M. L Sri Siddhartha Medical College, Agalakote, Tumkur, Karnataka, India
  • Dr. Punyashree R Sri Siddhartha Medical College, Agalakote, Tumkur, Karnataka, India
Keywords: Polycythemia, Hypoglycemia, Birth asphyxia, Gestational diabetes mellitus

Abstract

Introduction: Gestational diabetes mellitus has become the nightmare of the modern mothers due to its varied ill effects on the baby. As many of the ill effects can be well taken care with proper education, anticipation and expertise of newborn care taker, this study will throw light on the incidence of those ill effects.

Material & methods: It’s a prospective case control study done over a span of one year in a rural medical college in Karnataka.

Result: Large for gestational age, Congenital anomalies, Respiratory distress syndrome, Polycythemia, Hypoglycemia were the complications significantly associated with gestational diabetes mellitus.

Conclusion: Even our study emphasised the ill effects of gestational diabetes on the baby, RDS, Large baby, Metabolic disorders, Congenital anomalies, polycythemia were significantly associated with gestational diabetes. Most of the complications of GDM on babies are manageable and outcome can be drastically improved. Early diagnosis, education and anticipation of the complications and prompt referral are the need of the hour in peripheries and advancement of neonatal intensive cares in the referral hospitals is needed.

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References

1. Barnes-Powell LL. Infants of diabetic mothers: the effects of hyperglycemia on the fetus and neonate. Neonatal Netw. 2007 Sep-Oct. 26(5):283-90.DOI: DOI: 10.1891/0730-0832.26.5.283. [PubMed]

2. Plagemann A. A matter of insulin: developmental programming of body weight regulation. J Matern Fetal Neonatal Med. 2008 Mar. 21(3):143-8. DOI: 10.1080/14767050801929869.

3. Boney CM, Verma A, Tucker R, Vohr BR. Metabolic syndrome in childhood: association with birth weight, maternal obesity, and gestational diabetes mellitus. Pediatrics. 2005 Mar. 115(3):290-6. DOI: 10.1542/peds.2004-1808.

4. Mäkelä J, Lagström H, Kaljonen A, Simell O, Niinikoski H. Hyperglycemia and lower diet quality in pregnant overweight women and increased infant size at birth and at 13months of age - STEPS study. Early Hum Dev. 2013 Jun. 89(6):439-44. DOI: 10.1016/j.earlhumdev.2013.01.007. [PubMed]

5. Plagemann A, Harder T, Rodekamp E, Kohlhoff R. Rapid neonatal weight gain increases risk of childhood overweight in offspring of diabetic mothers. J Perinat Med. 2012 Sep. 40(5):557-63. DOI: 10.1515/jpm-2011-0270. [PubMed]

6. Maayan-Metzger A, Schushan-Eisen I, Strauss T, Globus O, Leibovitch L. Gestational weight gain and body mass indexes have an impact on the outcomes of diabetic mothers and infants. Acta Paediatr. 2015 Nov. 104 (11):1150-5. doi: 10.1111/apa.13166. [PubMed]

7. Elmekkawi SF, Mansour GM, Elsafty MS, Hassanin AS, Laban M, Elsayed HM. Prediction of Fetal Hypertrophic Cardiomyopathy in Diabetic Pregnancies Compared with Postnatal Outcome. Clin Med Insights Womens Health. 2015. 8:39-43. doi: 10.7860/JCDR/2016/17993.8079.

8. DeBoer T, Wewerka S, Bauer PJ, Georgieff MK, Nelson CA. Explicit memory performance in infants of diabetic mothers at 1 year of age. Dev Med Child Neurol. 2005 Aug;47(8):525-31. [PubMed]

9. Bromiker R, Rachamim A, Hammerman C, Schimmel M, Kaplan M, Medoff-Cooper B. Immature sucking patterns in infants of mothers with diabetes. J Pediatr. 2006 Nov;149(5):640-3. [PubMed]

10. Rosenkrantz TS, Knox I, Zalneraitis EL, et al. Cerebral metabolism and electrocortical activity in the chronically hyperglycemic fetal lamb. Am J Physiol. 1993 Dec. 265(6 Pt 2):R1262-9. PMID: 8285266.

11. Smiti Nanda, Umber Agarwal, Harbans Lal, et al. Absence of fasting hyperglycemia in Gestational Diabetics as a predictor of good perinatal outcome in high risk population- A study from northern India. Indian Medical Gazette, March (2002), 75-77.

12. A.Wiznitzer, D.Fraser, S.Weitzman et al. A prospective clinical trial of gestational diabetes vs. controls: Perinatal Outcomes. Am J Obstet Gynecol, 178(1): 53-60.

13. MacFarlane C M, Tsakalakos N. Relative fetal hypoxia as a contributing factor to fetal macrosomia in diabetic pregnancy. Medical Hypothesis, 1983, 11: 365-374.

14. Tamura R K, Sabbagha R E, Depp R et al: Diabetic macrosomia: Accuracy of third trimester ultrasound. Obstet Gynecol, 1986, 67:828-834. [PubMed]

15. Mills J L: Malformations in infants of diabetic mothers. Teratology, 1982, 25: 385. DOI: 10.1002/bdra.20757. [PubMed]

16. Pinter E, Reece E A, Leranth C Z, et al. Yolk sac failure in embryopathy due to hyperglycaemia. Teratology, 1986, 33 (1): 73-84. DOI: 10.1002/tera.1420330110. [PubMed]

17. Hod M, Star S, Passonnequ J V, et al. Effect of hyperglycemia on sorbitol and myoinositol content of cultured rat conceptus : Failure of aldose reductase inhibitors to modify myoinositol depletion and dysmorphogenesis. Biochem Biophys Res Commun, 1986, 140: 974.

18. Goldman A S, Baker L, Piddington R, et al Hyperglycaemia induced teratogenesis is mediated by a functional deficiency of arachidonic acid. Proceedings of the National Academy of Sciences of the USA, 1985, 82(23): 8227-8231.

19. Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes Care. 1997 Jul;20(7):1183-97. [PubMed]

20. Hollingsworth DR, Grundy S M. Pregnancy associated hypertriglyceridemia in normal and diabetic women: Differences in insulin dependent, non-insulin dependent and gestational diabetes. Diabetes, 1982, 31: 1092-1097.

21. Mansha Dubey. Diabetes in Pregnancy. JAMA India- The Physicians' Update 4(12): 66-68.

22. Das UN. Gestational diabetes mellitus. J Assoc Physicians India. 2001 Mar;49:361-5. [PubMed]

23. Salvesen DR, Brudenell MJ, Nicolaides KH. Fetal polycythemia and thrombocytopenia in pregnancies complicated by maternal diabetes mellitus. Am J Obstet Gynecol. 1992 Apr;166(4):1287-93.

24. Kristina M. Adams, Hongzhe Li, Roger L. Nelson et al. Sequelae of unrecognized gestational diabetes. Am J Obstet Gynecol, 1998, 178(6): 1321-1331. [PubMed]

25. Aberg A, Rydhstroem H, Frid A. Impaired glucose tolerance associated with adverse pregnancy outcome: a population-based study in southern Sweden. Am J Obstet Gynecol. 2001 Jan;184(2):77-83. [PubMed]
A study of effect of gestational diabetes on the newborn
CITATION
DOI: 10.17511/ijpr.2017.i05.03
Published: 2017-05-31
How to Cite
Dr. Rajith. M. L, & Dr. Punyashree R. (2017). A study of effect of gestational diabetes on the newborn. Pediatric Review: International Journal of Pediatric Research, 4(5), 303-309. https://doi.org/10.17511/ijpr.2017.i05.03
Section
Original Article