Association between iron deficiency anemia and febrile seizures
Keywords:
Febrile Seizure, Iron Deficiency Anemia, Plasma Ferritin
Abstract
Background: Febrile seizure is a common cause of seizure in young children, with an excellent prognosis. There is high prevalence of febrile seizure and iron deficiency anemia in preschool children, the aim of this study was to investigate the role of iron deficiency anemia in simple febrile seizure patients.
Methods: This prospective case-control study was performed in 50 children with simple febrile seizures (cases) and 50 febrile children without seizures (control), referred to Tata Motors Hospital, Jamshedpur. All children were aged between 6 months-5year. The groups were matched in age, gender, height and weight. Laboratory investigations performed were complete blood count, serum electrolytes, liver function test and renal functions test. Specific test advised were hemoglobin (Hb), (MCH), Mean corpuscular volume (MCV), mean corpuscular hemoglobin concentration (MCHC), and plasma ferritin (PF).
Results: There is lower value of hematological indices like mean Hemoglobin, Mean corpuscular hemoglobin, Mean corpuscular volume, Mean corpuscular hemoglobin concentration and Serum Ferritin in the cases group compared to the control group but no statistically significant difference.
Conclusion: This study did not establish any association between iron deficiency anemia and febrile seizures.
Downloads
Download data is not yet available.
References
1. Daoud A. Febrile convulsion: review and update. J Pediatr Neurolog. 2004; 2:9-14.
2. Sadinejad M, Mohsenzadeh A. Determinatine serum level of magnesium in children with febrile seizures.J Nutr Sci Vitaminol (Tokyo). 2005;7:105–8
3.Al-Ajlouni SF, Kodah IH. Febrile convulsions in children. Neurosciences (Riyadh). 2000 Jul;5(3):151-5. [PubMed]
4. Leung AK, Robson WL. Febrile seizures. J Pediatr Health Care. 2007 Jul-Aug;21(4):250-5. [PubMed]
5. Mikati MA, Kliegman RM, Behrman RE, Stanton BF. Seizures in childhood; Nelson textbook of Paediatrics, 19th edition. Philadelphia. 2011: WB Saunders [586]: 2013-2018.
6. Vestergaard M, Basso O, Henriksen TB, Ostergaard J, Olsen J. Febrile convulsions and sudden infant death syndrome. Arch Dis Child. 2002 Feb;86(2):125–126. doi: 10.1136/adc.86.2.125. [PubMed]
7. Knight M, Ebert J, Parish RA, Berry H, Fogelson MH. gamma-Aminobutyric acid in CSF of children with febrile seizures. Arch Neurol. 1985 May;42(5):474-5. doi: 10.1001/archneur.1985.04060050076011. [PubMed]
8. Kawakami Y, Fukunaga Y, Kuwabara K, Fujita T, Fujino O, Hashimoto K. Clinical and immunological significance of neopterin measurement in cerebrospinal fluid in patients with febrile convulsions. Brain Dev. 1999 Oct;21(7):458-60. doi: http://dx.doi.org/10.1016/S0387-7604(99)00052-2.
9. Berg AT, Shinnar S, Shapiro ED, Salomon ME, Crain EF, Hauser WA. Risk factors for a first febrile seizure: a matched case-control study. Epilepsia. 1995 Apr;36(4):334-41. doi: 10.1111/j.1528-1157.1995.tb01006.x [PubMed]
10. Sherjil A, us Saeed Z, Shehzad S, Amjad R. Iron deficiency anaemia- a risk factor for febrile seizures in children, J Ayub Med Coll Abbottabad. 2010 Jul-Sep;22(3):71-73. [PubMed]
11. Hartfield D. Iron deficiency is a public health problem in Canadian infants and children. Paediatr Child Health. 2010 Jul-Aug;15(6):347–50. PubMed PMID: 21731416. [PubMed]
12. Heydarian F, Vatankhah H. The role of anemia in first simple febrile seizure in children aged 6 months to 5 years old. Neurosciences (Riyadh). 2012 Jul;17(3):226–9.
13. Kumari PL, Nair MK, Nair SM, Kailas L, Geetha S. Iron deficiency as a risk factor for simple febrile seizures--a case control study. Indian Pediatr. 2012 Jan;49(1):17–9. PubMed PMID: 21719928. [PubMed]
14. Beard JL, Erikson KM, Jones BC. Neurobehavioral analysis of developmental iron deficiency in rats.Behav Brain Res. 2002Aug 21;134(1-2):517–24. [PubMed]
15. Rouault TA, Cooperman S. Brain iron metabolism.Semin Pediatr Neurol. 2006 Sep;13(3):142–8. [PubMed]
16. Badaracco ME, Siri MV, Pasquini JM. Oligodendrogenesis: the role of iron, Biofactors. 2010 Mar-Apr; 36(2):98-102. doi: 10.1002/biof.90. [PubMed]
17. Erikson KM, Jones BC, Hess EJ, Zhang Q, Beard JL. Iron deficiency decreases dopamine D1 and D2 receptors in rat brain. Pharmacol Biochem Behav. 2001 Jul-Aug;69(3-4):409–18. [PubMed]
18. Chen Q, Beard JL, Jones BC. Abnormal rat brain monoamine metabolism in iron deficiency anemia. J Nutr Biochem. 1995; 6(9):486–93. [PubMed]
19. Pisacane A, Sansone R, Impagliazzo N, Coppola A, Rolando P, D’Apuzzo A , et al. Iron deficiency anaemia and febrile convulsions: case–control study in children under 2 years. BMJ. 1996 Aug10; 313(7053):343. doi: 10.1136/bmj.313.7053.343. [PubMed]
20. Uhari M, Rntala H, Vainionpää L, and Kurttila R. Effect of Acetaminophen and of low dose intermittent Diazepam on prevention of recurrences of febrile seizure. J Pediatr. 1995 Jun; 126(6): 991-5. [PubMed]
21. Van stuijvenberg M, Derksen-Lubsen G, Steyerberg EW, Habbema JDF, Henriëtte A. Randomized, controlled trial of ibuprofen syrup administered during febrile illnesses to prevent febrile seizure recurrences. Pediatrics. 1998; 102(5): 51. doi: 10.1542/peds.102.5.e51
22. Kobrinsky NL, Yager JY, Cheang MS, Yatscoff RW, Tenenbein M. Does iron deficiency raise the seizure threshold? J Child Neurol. 1995 Mar; 10(2):105–9. doi: 10.1177/088307389501000207. [PubMed]
23. Naveed-ur-Rehman. Billoo AG. Association between iron deficiency anemia and febrile seizures. J Coll Phys Surg Pak. 2005 Jun;15(6):338–40. [PubMed]
24. Goldan Millichap J. Iron insufficiency as a risk factor for febrile seizures. AAP Grand Rounds,8(6)(2002), pp62–63. [PubMed]
25. Hartfield DS, Tan J, Yager JY, Rosychuk RJ, Spady D, Haines C, Craig W. The association between Iron deficiency and febrile seizure in childhood. Clin Pediatr (Phila). 2009 May;48(4):420-6. doi: 10.1177/0009922809331800. [PubMed]
26. Daoud AS, Batieha A, Abu-Ekteish F, Gharailbeh N, Ajlouni S, Hijazi S. Iron status: a possible risk factor for the first febrile seizure. Epilepsia 2002 Jul; 43(7):740-3. . doi: 10.1046/j.1528-1157.2002.32501.x [PubMed]
27. Bidabadi E, Mashouf M. Association between iron deficiency anemia and first febrile convulsion: A case-control study. Seizure. 2009 Jun; 18(5):347–51. . doi: 10.1016/j.seizure.2009.01.008. [PubMed]
28. Taylor MRH Holland CV,Spencer R, Jackson JF, O’ Connor GI, O’Donnell JR. Hematological reference range for school children. Clin Lab Haematol. 1997 Mar;19(1):1-15. [PubMed]
29. Jun YS, Bang HI, Yu ST, Shin SR, Choi DY. Relationship between iron deficiency anemia and febrile convulsion in infants. Korean J Pediatr.2010 Mar;53(3):392-396. doi:http://dx.doi.org/10.3345/kjp.2010.53.3.392.
30. Vaswani RK, Dharaskar PG, Kulkarni S, Ghosh K. Iron deficiency as a risk factor for first febrile seizure. Indian Pediatr. 2010 May;47(5): 437 439. [PubMed]
31. Im S, Ah JK, Choi BJ, Lee IG, Whang KT. The Relationship between Iron Deficiency Anemia and Febrile Seizure. J Korean Child Neurol Soc. 2003 May;11(1):55-60.
32. Huang, C.C., Wang, S.T., Chang, Y.C., Huang, M.C., Chi, Y.C., and Tsai, J.J. Risk factors for a first febrile convulsion in children: a population study in southern Taiwan. Epilepsia. 1999 Jun; 40(6): 719–725
2. Sadinejad M, Mohsenzadeh A. Determinatine serum level of magnesium in children with febrile seizures.J Nutr Sci Vitaminol (Tokyo). 2005;7:105–8
3.Al-Ajlouni SF, Kodah IH. Febrile convulsions in children. Neurosciences (Riyadh). 2000 Jul;5(3):151-5. [PubMed]
4. Leung AK, Robson WL. Febrile seizures. J Pediatr Health Care. 2007 Jul-Aug;21(4):250-5. [PubMed]
5. Mikati MA, Kliegman RM, Behrman RE, Stanton BF. Seizures in childhood; Nelson textbook of Paediatrics, 19th edition. Philadelphia. 2011: WB Saunders [586]: 2013-2018.
6. Vestergaard M, Basso O, Henriksen TB, Ostergaard J, Olsen J. Febrile convulsions and sudden infant death syndrome. Arch Dis Child. 2002 Feb;86(2):125–126. doi: 10.1136/adc.86.2.125. [PubMed]
7. Knight M, Ebert J, Parish RA, Berry H, Fogelson MH. gamma-Aminobutyric acid in CSF of children with febrile seizures. Arch Neurol. 1985 May;42(5):474-5. doi: 10.1001/archneur.1985.04060050076011. [PubMed]
8. Kawakami Y, Fukunaga Y, Kuwabara K, Fujita T, Fujino O, Hashimoto K. Clinical and immunological significance of neopterin measurement in cerebrospinal fluid in patients with febrile convulsions. Brain Dev. 1999 Oct;21(7):458-60. doi: http://dx.doi.org/10.1016/S0387-7604(99)00052-2.
9. Berg AT, Shinnar S, Shapiro ED, Salomon ME, Crain EF, Hauser WA. Risk factors for a first febrile seizure: a matched case-control study. Epilepsia. 1995 Apr;36(4):334-41. doi: 10.1111/j.1528-1157.1995.tb01006.x [PubMed]
10. Sherjil A, us Saeed Z, Shehzad S, Amjad R. Iron deficiency anaemia- a risk factor for febrile seizures in children, J Ayub Med Coll Abbottabad. 2010 Jul-Sep;22(3):71-73. [PubMed]
11. Hartfield D. Iron deficiency is a public health problem in Canadian infants and children. Paediatr Child Health. 2010 Jul-Aug;15(6):347–50. PubMed PMID: 21731416. [PubMed]
12. Heydarian F, Vatankhah H. The role of anemia in first simple febrile seizure in children aged 6 months to 5 years old. Neurosciences (Riyadh). 2012 Jul;17(3):226–9.
13. Kumari PL, Nair MK, Nair SM, Kailas L, Geetha S. Iron deficiency as a risk factor for simple febrile seizures--a case control study. Indian Pediatr. 2012 Jan;49(1):17–9. PubMed PMID: 21719928. [PubMed]
14. Beard JL, Erikson KM, Jones BC. Neurobehavioral analysis of developmental iron deficiency in rats.Behav Brain Res. 2002Aug 21;134(1-2):517–24. [PubMed]
15. Rouault TA, Cooperman S. Brain iron metabolism.Semin Pediatr Neurol. 2006 Sep;13(3):142–8. [PubMed]
16. Badaracco ME, Siri MV, Pasquini JM. Oligodendrogenesis: the role of iron, Biofactors. 2010 Mar-Apr; 36(2):98-102. doi: 10.1002/biof.90. [PubMed]
17. Erikson KM, Jones BC, Hess EJ, Zhang Q, Beard JL. Iron deficiency decreases dopamine D1 and D2 receptors in rat brain. Pharmacol Biochem Behav. 2001 Jul-Aug;69(3-4):409–18. [PubMed]
18. Chen Q, Beard JL, Jones BC. Abnormal rat brain monoamine metabolism in iron deficiency anemia. J Nutr Biochem. 1995; 6(9):486–93. [PubMed]
19. Pisacane A, Sansone R, Impagliazzo N, Coppola A, Rolando P, D’Apuzzo A , et al. Iron deficiency anaemia and febrile convulsions: case–control study in children under 2 years. BMJ. 1996 Aug10; 313(7053):343. doi: 10.1136/bmj.313.7053.343. [PubMed]
20. Uhari M, Rntala H, Vainionpää L, and Kurttila R. Effect of Acetaminophen and of low dose intermittent Diazepam on prevention of recurrences of febrile seizure. J Pediatr. 1995 Jun; 126(6): 991-5. [PubMed]
21. Van stuijvenberg M, Derksen-Lubsen G, Steyerberg EW, Habbema JDF, Henriëtte A. Randomized, controlled trial of ibuprofen syrup administered during febrile illnesses to prevent febrile seizure recurrences. Pediatrics. 1998; 102(5): 51. doi: 10.1542/peds.102.5.e51
22. Kobrinsky NL, Yager JY, Cheang MS, Yatscoff RW, Tenenbein M. Does iron deficiency raise the seizure threshold? J Child Neurol. 1995 Mar; 10(2):105–9. doi: 10.1177/088307389501000207. [PubMed]
23. Naveed-ur-Rehman. Billoo AG. Association between iron deficiency anemia and febrile seizures. J Coll Phys Surg Pak. 2005 Jun;15(6):338–40. [PubMed]
24. Goldan Millichap J. Iron insufficiency as a risk factor for febrile seizures. AAP Grand Rounds,8(6)(2002), pp62–63. [PubMed]
25. Hartfield DS, Tan J, Yager JY, Rosychuk RJ, Spady D, Haines C, Craig W. The association between Iron deficiency and febrile seizure in childhood. Clin Pediatr (Phila). 2009 May;48(4):420-6. doi: 10.1177/0009922809331800. [PubMed]
26. Daoud AS, Batieha A, Abu-Ekteish F, Gharailbeh N, Ajlouni S, Hijazi S. Iron status: a possible risk factor for the first febrile seizure. Epilepsia 2002 Jul; 43(7):740-3. . doi: 10.1046/j.1528-1157.2002.32501.x [PubMed]
27. Bidabadi E, Mashouf M. Association between iron deficiency anemia and first febrile convulsion: A case-control study. Seizure. 2009 Jun; 18(5):347–51. . doi: 10.1016/j.seizure.2009.01.008. [PubMed]
28. Taylor MRH Holland CV,Spencer R, Jackson JF, O’ Connor GI, O’Donnell JR. Hematological reference range for school children. Clin Lab Haematol. 1997 Mar;19(1):1-15. [PubMed]
29. Jun YS, Bang HI, Yu ST, Shin SR, Choi DY. Relationship between iron deficiency anemia and febrile convulsion in infants. Korean J Pediatr.2010 Mar;53(3):392-396. doi:http://dx.doi.org/10.3345/kjp.2010.53.3.392.
30. Vaswani RK, Dharaskar PG, Kulkarni S, Ghosh K. Iron deficiency as a risk factor for first febrile seizure. Indian Pediatr. 2010 May;47(5): 437 439. [PubMed]
31. Im S, Ah JK, Choi BJ, Lee IG, Whang KT. The Relationship between Iron Deficiency Anemia and Febrile Seizure. J Korean Child Neurol Soc. 2003 May;11(1):55-60.
32. Huang, C.C., Wang, S.T., Chang, Y.C., Huang, M.C., Chi, Y.C., and Tsai, J.J. Risk factors for a first febrile convulsion in children: a population study in southern Taiwan. Epilepsia. 1999 Jun; 40(6): 719–725
CITATION
DOI: 10.17511/ijpr.2015.i04.02
Published: 2015-12-31
How to Cite
Dr Kunwar Bharat, Dr Rajesh K. Yadav, Dr Durgesh Kumar, Dr Amitesh Yadav, Dr Rajiv Sharan, & Dr Vineet Chaturvedi. (2015). Association between iron deficiency anemia and febrile seizures. Pediatric Review: International Journal of Pediatric Research, 2(4), 41-46. https://doi.org/10.17511/ijpr.2015.i04.02
Section
Original Article
Copyright (c) 2015 Author (s). Published by Siddharth Health Research and Social Welfare Society
This work is licensed under a Creative Commons Attribution 4.0 International License.
OAI - Open Archives Initiative
