T-Cell Rich B-Cell Lymphoma A diagnostic dilemma in paediatric oncology
Abstract
T-cell rich B-cell lymphoma, most commonly seen in adults and rarely reported in children is a type of Diffuse Large B cell Lymphoma. (DLBCL). It has several clinical, histological and immunohistochemical similarities to commonly Nodular lymphocyte predominant Hodgkin’s lymphoma. We report an 8 year-old boy who presented with a swelling over the right inguinal region for two months. FNAC of the swelling was inconclusive. MRI abdomen revealed multiple masses in right iliac fossa. Immunohistochemistry of the biopsy mass was consistent with T cell rich B cell lymphoma. T cell rich B cell lymphoma has a very low incidence in pediatric population and still remains unrecognized in most of the cases. When compared to adults, children have a better prognosis and hence stronger emphasis on immunohistochemistry is essential. Careful attention should be paid to differentiate the different neoplasms as each have a distinct course of clinical history and different therapies.
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References
2. Ramsay AD, Smith WJ, Isaacson PG. T-cell-rich B-cell lymphoma. Am J Surg Pathol. 1988 Jun;12(6):433-43. [PubMed]
3. Delabie J, Vandenberghe E, Kennes C, Verhoef G, Foschini MP, Stul M, Cassiman JJ, De Wolf-Peeters C. Histiocyte-richB-cell lymphoma. A distinctclinicopathologicentitypossiblyrelated to lymphocytepredominantHodgkin's disease, paragranulomasubtype.Am J Surg Pathol. 1992 Jan;16(1):37-48. [PubMed]
4. Gatter KC, Warnke RA, Macon WR, McCurley TL. Diffuse large B-cell lymphoma. In: Jaffe ES, Harris NL, Stein H, Vardiman JW, eds. WHO Classification of Tumours: Pathology and Genetics of Tumours of Haematopoietic and Lymphoid Tissues. Lyon, France : IARC Press; 2001:171–76.
5. Lones MA, Cairo MS, Perkins SL. T-cell-rich large B-cell lymphoma in children and adolescents: a clinicopathologic report of six cases from the Children's Cancer Group Study CCG- 5961. Cancer. 2000;88(10):2378-86.
6. Abramson JS. T-cell/histiocyte-rich B-cell lymphoma: biology, diagnosis, and management. Oncologist. 2006 Apr;11(4):384-92. [PubMed]
7. Fraga M, Sanchez-Verde L, Forteza J et al. T-cell/histiocyte-rich large B- cell lymphoma is a disseminated aggressive neoplasm: differential diagnosis from Hodgkin’s lymphoma. Histopathology. 2002;41(3):216–29. DOI: 10.1046/j.1365-2559.2002.01466. [PubMed]
8. Gabriela G, Hemalatha G R, Bruce C, Annette S, Steven K et al. T-cell/Histiocyte-Rich Large B-cell Lymphoma in Pediatric Patients: an Under-Recognized Entity?.Annals of Clinical & Laboratory Science. 2015:45(1)73-8.
9. Stein H, Delsol G, Pileri A et al. Nodular lymphocyte predominant Hodgkin lymphoma. In: Jaffe ES, Harris NL, Stein H et al., eds. Tumours of Haematopoietic and Lymphoid Tissues. Lyon: IARC Press, 2001:240–43.
10. Weshi A, Akhtar S, Mourad WA, et al. T-cell/histiocyte-rich B-cell lymphoma: Clinical presentation, management and prognostic factors: report on 61 patients and review of literature. Leuk Lymphoma. 2007;48:1764-73.http://dx.doi.org/10.1080/10428190701559124.
11. Tiemann M, Rienner MO, Claviez A et al. Proliferation rate and outcome in children with T cell rich B cell Lymphoma: a clinicopathologic study from the NHL-BFM study group. Leuk Lymphoma. 2005;46(9):1295-300.http://dx.doi.org/10.1080/10428190500083326.
12. McBride JA, Rodriguez J, Luthra R, et al. T-cell-rich B largecell lymphoma simulating lymphocyte-rich Hodgkin's disease. Am J Surg Pathol. 1996;20(2):193-201. [PubMed]
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