A study on clinico-etiological profile of chronic liver disease in children between 1year to 14 years of age

  • Dr. Aarti Behera Department of Paediatrics, S.C.B. Medical College Hospital, Cuttack, Odisha, India
  • Dr Mangal Charan Murmu Department of Paediatrics, S.C.B. Medical College Hospital, Cuttack, Odisha, India
Keywords: Liver Diseases, Biliary Atresia, Non-alcoholic fatty liver disease (NAFLD), Children

Abstract

Introduction: Chronic liver diseases(CLD) account for 1 to 5% of paediatric ward admissions and upto 20% of ward mortality in our country. Now a day Indian childhood cirrhosis is a rarity, whereas diseases likechronic hepatitis, Wilsons disease and biliary atresia are diagnosed with increasing frequency and therefore became relatively important forms of paediatric liver disease.

Methodology: The study was done to determine the clinico-etiological profile of chronic liver disease in children 1 year to 14 years. This is a prospective case-controlled study done over a period of two years. Various clinical, biochemical and radiographic parameters pertaining to chronic liver disease were studied.

Results: About4 0 cases were studied. CLD was found to be prevalent in 5-10 years of age group. Male were more affected than female. Jaundice was the most common presenting feature.Hepatomegaly, Ascitis, Splenomegaly were thecommonest presenting signs.

Conclusion: CLD is not uncommon condition in children. It constitutes 18.34% of the patients of the with liver disease in our region. Wilson’s disease was the most common aetiology apart from idiopathic which constitute 52.5% of the cause.

Downloads

Download data is not yet available.

References

1. Bhave S, Bavdekar A, Pandit A. Changing pattern of chronic liver disease (CLD) in India. Indian J Pediatr. 1994 Nov-Dec;61(6):675-82.

2. Sachin Devidas Dhole, Archana S. Kher, Radha G. Ghildiyal and Manjusha P. Tambse. Chronic Liver Diseases in Children: Clinical Profile and Histology: J Clin Diagn Res. 2015 Jul; 9(7): SC04–SC07.

3. Dar GA, Zarger SA, Jan K, Malik MI, Mir TA, Dar MA. Spectrum of Liver Diseases among Children in Kashmir Valley. Academic Medical Journal of India. 2014 Nov 20;2(3):80–6.

4. Mukherjee PS, Vishnubhatla S, Amarapurkar DN, Das K, Sood A, Chawla YK, et al. (2017) Etiology and mode of presentation of chronic liver diseases in India: A multi centric study. PLoS ONE 12(10): e0187033. https://doi. org/10.1371/journal.pone.0187033

5. Gulzar Ahmad Dar , Mohammad Ishaq Malik , Farooq Ahmad Ganie* , Kowsar Jan , Tariq Abdullah , Mohd Iqbal Dar and Maqsood Ahmad Dar; Chronic Liver Diseases in Children: Clinical Spectrum and Etiology BBB[2][2][2014]406-411.

6. Francesca Rinaldi, Enrico Brunetti, Andreas Neumayr, Marcello Maestri, Samuel Goblirsch, and Francesca Tamarozzi Cystic echinococcosis of the liver: A primer for hepatologists World J Hepatol. 2014 May 27; 6(5): 293–305.

7. Chaturvedi K, Vohra P. Non-alcoholic fatty liver disease in children. Indian Pediatr. 2012 Sep;49(9):757-8.

8. Akinbami FO, Venugopalan P, Nirmala V, Suresh J, Abiodun P. Pattern of chronic liver disease in Omani children: A clinicopathological review. West Afr J Med 2004; 23:162-6.

9. Hanif M, Raza J, Qureshi H, Issani Z. Etiology of chronicliver disease in children. J PakMedAssoc. 2004 Mar;54(3):119-22. [PubMed]

10. Dangwal T.R, Agrwal V, Malhotra V, Bavaga V and Mittal S.K. Clinical spectrum of chronic liver diseases in North India. Trop. Gastroenterol. 1997; 18 (4):184. [PubMed]

11. Hanif M, Raza J, Qureshi H, Issani Z. Etiology of chronic liver disease in children. J Pak Med Assoc. 2004 Mar;54(3):119-22.

12. Ira Shah ,Susmita Bhatnagar Clinical Profile of chronic hepatobiliary disorders in children: experience from tertiary referral centre in western India Tropical Gastroenterology2010;31(2):108–110.

13. Leuschner U. Primarybiliary cirrhosis--presentation and diagnosis. Clin Liver Dis. 2003 Nov;7(4):741-58.

14. Yachha SK, Sharma BC, Khanduri A, Srivastava A. Current spectrum of hepatobiliary disorders in northern India. Indian Pediatr. 1997 Oct;34(10):885-90.

15. Zhang HF, Yang XJ, Zhu SS, Zhao JM, Zhang TH, Xu ZQ, Chen DW, Wang SS, Chen JM. Pathologicalchanges and clinical manifestations of 1020children with liver diseasesconfirmed by biopsy. HepatobiliaryPancreatDis Int. 2004 Aug;3(3):395-8.

16. Rafeey M, Kianrad M, Hasani A. Autoimmune hepatitis in Iranian children. Indian J Gastroenterol. 2007 Jan-Feb;26(1):11-3.

17. Rajeshwari K, Gogia S. The clinical spectrum of chronic liver disease in children presenting to a tertiary level teaching hospital in New Delhi. Trop Doct 2008; 38:101-102.
A study on clinico-etiological profile of chronic liver disease in children between 1year to 14 years of age
CITATION
DOI: 10.17511/ijpr.2018.i01.07
Published: 2018-01-31
How to Cite
Dr. Aarti Behera, & Dr Mangal Charan Murmu. (2018). A study on clinico-etiological profile of chronic liver disease in children between 1year to 14 years of age. Pediatric Review: International Journal of Pediatric Research, 5(1), 31-36. https://doi.org/10.17511/ijpr.2018.i01.07
Section
Original Article