Lipid profile in children with Nephrotic syndrome
Abstract
Background: To study the derangement of serum lipid profile in children 2 to 12 years with nephrotic syndrome.
Methods: 50 children 2 to 12 years with nephrotic syndrome were identified. Patients were classified as remission, relapse and newly diagnosed. Lipid Profile was measured. Patients were followed-up after 4 weeks of steroid therapy.
Results: Out of all the 50 subjects screened, 25 (50%) subjects had high total cholesterol, 26 (52%) had high triglyceride, 8 (16%) had abnormal HDL cholesterol and 25 (50%) had high LDL cholesterol. After 4 weeks of steroid therapy though there was significant reduction in lipid components.
Conclusion: Our study shows that in nephrotic syndrome, there is generalised hyperlipidemia and hypoalbuminemia. Serum cholesterol, triglycerides and LDL cholesterol were deranged in almost all subjects. In cases in relapse after 4 weeks of steroid therapy there is persistent raised total cholesterol, triglycerides and LDL cholesterol, which may predispose to the development of atherosclerosis in near future.
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References
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Copyright (c) 2018 Author (s). Published by Siddharth Health Research and Social Welfare Society
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