Study of incidence and severity of thrombocytopenia in childhood malaria and response to antimalarial therapy in a tertiary care hospital
Abstract
Background: Malaria is a significant cause of morbidity and mortality all over world and India contributes a significant proportion of disease. There is relative paucity of data in children regarding incidence of thrombocytopenia, its severity, clinical manifestations and response to anti-malarial treatment.
Materials and methods: The study conducted in a tertiary care hospital in south Rajasthan in over a period of one year includes 168 children less than 16 years with diagnosed case of malaria. Data were collected according to the medical records observation technique.
Results: We found significant association of thrombocytopenia in malaria. Majority of cases with thrombocytopenia were plasmodium vivax positive, range of platelet count was 16000/cumm to 3.2lacs/cumm. Despite severe thrombocytopenia, no child had bleeding manifestations and response to treatment was significant and platelet transfusion was given to none.
Conclusion: Thrombocytopenia in a febrile child in endemic zones should alert the physician towards the possibility of malaria. Moreover even in cases of severe thrombocytopenia, one should not panic and shouldgive anti-malarial and appropriate supportive therapy as bleeding manifestations are rare and response to therapy is good.
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