Effect of vitamin D supplementation in severity and control of bronchial asthma in children

  • Dr. Aneeta Agrahari Department of Pathology, Sarojini Naidu Medical College, Agra, India.
  • Dr. Rajeshwar Dayal Professor & Head,Department of Pathology, Sarojini Naidu Medical College, Agra, India.
  • Dr. L.K. Gupta Senior Consultant, District Women Hospital, Firozabad.
  • Dr. Rakesh Bhatia Professor, Department of Pediatrics,Sarojini Naidu Medical College, Agra, India.
  • Dr. Dipti Agarwal Associate Professor, Department of Pediatrics, Ram Manohar Lohia Institute of Medical Sciences, Lucknow.
  • Dr. Pankaj Kumar Associate Professor,Department of Pathology, Sarojini Naidu Medical College, Agra, India.
  • Dr. Sunit Pathak Associate Professor, Department of Paediatrics, F.H. Medical College, Tundla, Firozabad
  • Dr. Harendra Kumar Associate Professor,Department of Pathology, Sarojini Naidu Medical College, Agra, India.
DOI: https://doi.org/10.17511/ijpr.2019.i02.01
Keywords: Asthmatic children, Vitamin D, Severity of asthma

Abstract

Background: Asthma is characterized by chronic airway inflammation with history of recurrent respiratory symptoms such as wheeze, breathlessness, chest tightness, cough.

Methodology: A prospective interventional study was conducted in Department of Paediatrics, S. N. Medical and Hospital, Agra. About 141 asthmatic children of age group ≤ 14years of either gender were selected. Baseline serum vitamin D level was done and children were divided in to two groups. Group A and Group B. Only moderate persistent severity children were included for further follow up study, based on Vitamin-D levels. Outcome was measured at 3 & 6 months, in all the groups in the form of Emergency-room visit per month, ACT score and Reliever-medication use per-week.

Results: Among 141 patients, 49.7% were 9-14years old, 53.9% were males and 84.4% suffering from moderate-persistent asthma. Mean Vitamin-D was significantly-lower in asthma patients with increasing severity. After starting standard-therapy and Vitamin-D supplementation, there was decrease in emergency-room visit and hospital-admission, decrease in requirement of reliever-medication for asthma and improvement in asthma control score. There was significant increase in ACT-score from 3 to 6 months follow-ups in all groups with highest score in subgroup-B2 patients.

Conclusion: Vitamin-D supplementation was beneficial in asthma patients for relieving asthma exacerbation such as symptoms, reducing hospital-admission and emergency hospital visits.

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Effect of vitamin D supplementation in severity and control of bronchial asthma in children
CITATION
DOI: 10.17511/ijpr.2019.i02.01
Published: 2019-02-28
How to Cite
Dr. Aneeta Agrahari, Dr. Rajeshwar Dayal, Dr. L.K. Gupta, Dr. Rakesh Bhatia, Dr. Dipti Agarwal, Dr. Pankaj Kumar, Dr. Sunit Pathak, & Dr. Harendra Kumar. (2019). Effect of vitamin D supplementation in severity and control of bronchial asthma in children. Pediatric Review: International Journal of Pediatric Research, 6(2), 50-57. https://doi.org/10.17511/ijpr.2019.i02.01
Issue
Vol 6 No 2 (2019): FEBRUARY
Section
Original Article