Effectiveness of predicting outcome in septic shock in critically ill children by assessing serum lactate levels
Abstract
Background and Aims: Hyperlactatemia at the time of admission is a documented risk factor for mortality in critically ill adult patients. However, the significance of lactate measurement at admission for mortality in critically ill children remains uncertain. This study evaluated the predictive value of blood lactate levels at the time of admission and determined the cut-off values for predicting in-hospital mortality in the critically ill children.
Materials and Methods: A total of 60 children with diagnosis of sepsis admitted to PICU of a tertiary care hospital were included in the study. PRISM III score and demographic characteristics of all children were recorded. Serum lactate levels were measured at 0-3, 12 and 24 h of PICU admission. The outcome like survival or death was correlated with serum lactate levels.
Results: Septic shock was the most common type of shock and had highest mortality. Lactate levels were significantly higher in non survivors in comparison to survivors. A lactate value of more than 5 mmol/l at 0-3, 12 and 24h of PICU admission had increased mortality.
Conclusions: A high blood lactate level at admission is independently associated with higher in-hospital mortality in the critically ill children.
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References
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