Solid tumors in neonates: demographic pattern and management in a tertiary care centre
Abstract
Background: Neonatal solid tumors are different in their clinical and biological behavior from older children. Rarity of these tumors, histological diversity and paucity of information leads to difficulty in diagnosis and management. The objective of the study is to analyse the demographic pattern, clinico-pathological features and management of neonatal solid tumors along with comparing the outcome with similar available studies.
Methods: The retrospective study was carried out in a tertiary care pediatric institute between April 2014 and March 2019. The medical records of neonates admitted and operated for solid tumors were analysed. The incidence, clinical presentation, pathological findings, management and outcome were studied.
Results: Out of 85 children operated for solid tumors, 24 cases were presented and operated in neonatal period. Sacrococcygeal teratoma (17 cases) was the most common neoplasm followed by retroperitoneal teratoma (3 cases). The male to female ratio in sacrococcygeal teratoma was almost equal in the present study. Two neonates with congenital mesoblastic nephroma and a 5-day girl with biphasic pulmonary blastoma were remarkable findings in this study. There was no mortality or tumor recurrence during postoperative period and follow up.
Conclusions: Neonatal tumors are rare neoplasms and are different in their clinical and biological behavior from older children. The rarity, histological diversity and paucity of information leads to difficulty in diagnosis and management. Benign tumors may have aggressive appearance, but prognosis is good after complete surgical excision. Multidisciplinary methodological management approach is essential for optimal survival of these tiny neonates.
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References
Orbach D, Sarnacki S, Brisse HJ, Villars MG, Jarreau PH, Tsatsaris V, et al. Neonatal cancer. Lancet Oncol. 2013;14(13): e609-e620. doi: 10.1016/S1470-2045(13) 70236-5.
Moore SW. Neonatal tumors. Pediatr Surg Int. 2013;29 (12): 1217-1229.doi: 10.1007/s00383-013-3424-3.
Desdandes E, Guissou S, Ducassou S, Lacour B. Neonatal solid tumors: incidence and survival in France. Pediatr Blood Cancer. 2016;63(8);1375-1380. doi:10.1002/pbc.26006.
Chandrasekaran A. Neonatal solid tumors. Pediatr Neonatal. 2018;59(1):65-70. doi: 10.1016/j.pedneo. 2016.12.007.
Charles AK. Congenital tumors. In: Jean W Keeling, T Yee Khong. Editors. Fetal and Neonatal Pathology 4th Ed. London: Springer 2007.Pp. 327-378.
Raciborska A, Bilska K, Węcławek-Tompol J, Ussowicz M, Pogorzała M, Janowska J, et al. Solid Cancers in the Premature and the Newborn: Report of Three National Referral Centers. Pediatr Neonatol. 2016;57(4):295-301. doi: 10.1016/j.pedneo. 2015.08. 007.
Altman RP, Randolph JG, Lilly JR. Sacrococcygeal teratoma: American Academy of Pediatrics Surgical Survey-1973. J Pediatr Surg. 1974;9(3):389-398. doi:10.1016/s0022-3468(74)80297-6.
Sinha S, Sarin YK, Deshpande VP. Neonatal sacrococcygeal teratoma: Our experience with 10 cases. J Neonatal Surg 2013;2(1):4.
Aly KAE, Shoier M, Badrawy T. Sacrococcygeal teratoma: a neonatal surgical problem. Ann Pediatr Surg. 2006; 2(2):106-111.
Bedabrata M, Das C, Sengupta M, Saha AK, Mukhopadhyay M, Mukhopadhyay B. An epidemiological review of sacrococcygeal teratoma over five years in a tertiary care hospital. Ind J Med Pediatr Oncol. 2018;39(1):4-7. doi: 10.4103/ijmpo. ijmpo_239_14.
Stevens MCG. Neonatal tumors.Arch Dis Child. 1988; 63:1122-1125.
Rescorla FJ. Teratoma and other germ cell tumors. In: Coran AG, Adzick NS, Krummel TM, Laberge J, Shamberger RC, Caldmone AA. Editors. Pediatric Surgery. 7th ed. Philadelphia: Elsevier Saunders 2012. Pp. 507-16.
Choudhury SR, Debnath PR, Pant N, Chowdhary L. Congenital immature teratoma of the retroperitoneum. J Neonatal Surg. 2013;2(3):33. eCollection 2013 Jul-Sep.
Annigeri VM, Bhuvanesh A, Gadgade BD, Halgeri AB. Giant retroperitoneal mature cystic teratoma in an infant: A case report. J Pediatr Neonatal Care. 2016;5 (7):00212. doi: 10.15406/jpnc.2016.05.00212
Tripathy PK, Pattnaik K, Jena PK, Mohanty HK. Retroperitoneal mature cystic teratoma in a 3-month-old infant: A case report and literature review. Indian J Med Paediatr Oncol. 2018;39(1):117-119. doi: 10.4103/ ijmpo.ijmpo_42_17.
Aldhilan A, Alenezi K, Alamer A, Aldhilan S, Alghofaily K, Alotaibi M. Retroperitoneal teratoma in 4 months old girl: Radiology and pathology correlation. Curr Pediatr Res. 2013;17(2):133-136.
Chaudhary A, Misra S, Wakhlu A, Tandon RK, Wakhlu AK. Retroperitoneal teratomas in children. Indian J Pediatr. 2006;73(3):221-223. doi: 10.1007/ bf02825485
Tripathy PK, Behera S, Mohanty HK. Cellular Congenital Mesoblastic Nephroma in a Newborn. J Neonat Surg. 2017;6(2):45. doi: 10.21699/jns.v6i2.564.
Wang ZP, Li K, Dong KR, Xiao XM, Zheng S. Congenital mesoblastic nephroma: Clinical analysis of eight cases and a review of the literature. Oncol Lett. 2014;8(5):2007-2011. Epub 2014 Sep 1. doi: 10.3892/ ol.2014.2489.
Mallya V, Arora R, Gupta K. Congenital Mesoblastic Nephroma: A Rare Pediatric Neoplasm/ Kongenital Mezoblastik Nefrom: Nadir Bir Pediatrik Tümör. Turk J Pathol. 2013;29(1):58-60. doi: https://doi.org/10.5146/tjpath.2013.01149.
Wahid FN, Malkan AD, Bahrami A, Pappo AS, Sandoval JA, Fernandez-Pineda I, Rao BN. Primary lung tumors in children and adolescents:29 years of experience at a single institution. Clin Surg.2017; 2:1666.
Dishop MK, Kuruvilla S. Primary and metastatic lung tumors in the pediatric population: a review and 25-year experience at a large children's hospital. Arch Pathol Lab Med. 2008;132(7):1079-1103. doi: 10.1043/ 1543-2165 (2008)132 [1079:PAMLTI] 2.0.CO;2.
de Kock L, Bah I, Brunet J, Druker H, Astigarraga I, Bosch-Barrera J, et al. Somatic DICER1 mutations in adult-onset pulmonary blastoma. Europe Resp J. 2016;47(6):1879-1882. doi: 10.1183/13993003.00172-2016.
Brambilla E, Travis WD, Colby TV, Corrin B, Shimosato Y. The new World Health Organization classification of lung tumours. Eur Respir J. 2001;18 (6):1059-1068. doi: 10.1183/09031936. 01.00275301.
Smyth RJ, Fabre A, Dodd JD, Bartosik W, Gallagher CG, McKone EF. Pulmonary blastoma: a case report and review of the literature. BMC Res Notes. 2014; 7:294. doi: 10.1186/1756-0500-7-294.
Alahwal MS, Maniyar IH, Saleem F, Alshiekh M. Pulmonary blastoma: a rare primary lung malignancy. Case Rep Med. 2012; 2012:471613. doi: 10.1155/ 2012/471613. Epub 2012 Sep 19.
Cutler CS, Michel RP, Yassa M, Langleben A. Pulmonary blastoma: case report of a patient with a 7‐year remission and review of chemotherapy experience in the world literature. Cancer: Interdisciplinary Int J Am Cancer Soc. 1998;82(3):462-467.
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