A case study report of denovo lymph node occurance of myeloid sarcoma

  • Dr. D. Raveendra Naik GSL Medical College Rajahmundry, India.
  • Dr. J V B Sankara Rao GSL Medical College Rajahmundry, India.
  • Dr. T V Ramesh GSL Medical College Rajahmundry, India.
  • Dr. Y.S Sarma GSL Medical College Rajahmundry, India.
  • Dr. Keerthi Priya Konkay GSL Medical College Rajahmundry, India.
Keywords: Lymphnode Biopsy, Immunohistochemistry, KP1 (CD68), Myeloid Sarcoma

Abstract

Myeloid sarcoma (MS) as a rare localized solid tumor mass consists of myeloblasts or immature myeloid cells was found in an extramedullary site of a 4 year male child who was suffering with fever, abdominal distension since 4 months and swelling of legs from 1month . On examining pallor, bilateral cervical and inguinal lymphadenopathy, bilateral pitting pedal edema, Hepatosplenomegaly & ascites found. On investigation anemia with leukocytosis, thrombocytopenia was found. USG abdomen showed multiple non necrotic lymphnodes. Bone marrow aspiration suggestive of JMML, lymphnode biopsy showed myeloid sarcoma and was confirmed by immune histochemistry (IHC) markers LCA, KP-1(CD68), myeloperoxidase are positive.Immunophenotyping is useful in differentiating myeloid sarcoma from lymphoma and leukaemia. Child was treated with 3/7 regimen of cytoarabinoside, daunorubicin.

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References

1. Brunning RD, Matutes E, Flandrin G, Vardiman J, Bennett J, Head D, et al. Acute myeloid leukaemia not otherwise categorised. In: Jaffe ES, Stein H, Vardiman JW, editors. Tumors of Hematopoietic and Lymphoid Tissues. Lyon: IARC Press; 2001. pp. 104–5.

2. Pileri S.A., Ascani S., Cox M., Campidelli C., Bacci F., Piccioli M., et al. (2007) Myeloid sarcoma: Clinicopathologic, phenotypic and cytogenetic analysis of 92 adult patients. Leukemia 21: 340–350.

3. Tsimberidou AM, Kantarjian HM, Wen S, Keating MJ, O'Brien S, Brandt M, Pierce S, Freireich EJ, Medeiros LJ, Estey E. Myeloid sarcoma is associated with superior event-free survival and overall survival compared with acute myeloid leukemia. Cancer. 2008 Sep 15;113(6):1370-8. doi: 10.1002/cncr.23691.

4. Cunningham I. Extramedullary sites of leukemia relapse after transplant. Leuk Lymphoma. 2006 Sep; 47(9):1754-67. [PubMed]

5. Audouin J, Comperat E, Le Tourneau A, Camilleri-Broët S, Adida C, Molina T, Diebold J. Myeloid sarcoma: clinical and morphologic criteria useful for diagnosis. Int J Surg Pathol. 2003 Oct; 11(4):271-82. [PubMed]

6. Rappaport H. Tumors of the hematopoietic system. Armed Forces Inst Pathol 1966; 3:241-43. [PubMed]

7. Szomor A, Passweg JR, Tichelli A, Hoffmann T, Speck B, Gratwohl A. Myeloid leukemia and myelodysplastic syndrome relapsing as granulocytic sarcoma (chloroma) after allogeneicbone marrow transplantation. Ann Hematol. 1997 Nov-Dec; 75(5-6):239-41. [PubMed]

8.Lan TY, Lin DT, Tien HF, Yang RS, Chen CY, Wu K. Prognostic factors of treatment outcomes in patients with granulocytic sarcoma. Acta Haematol. 2009;122(4):238-46. doi: 10.1159/000253592. Epub 2009 Oct 30. [PubMed]

9. Maeng H, Cheong JW, Lee ST, et al.Isolated extramedullary relapse of acute myelogenous leukemia as a uterine granulocytic sarcoma in an allogeneic hematopoietic stem cell transplantation recipient. Yonsei Med J.2004; 45:330–3.
A case study report of denovo lymph node occurance of myeloid sarcoma
CITATION
DOI: 10.17511/ijpr.2016.i01.14
Published: 2016-01-31
How to Cite
Dr. D. Raveendra Naik, Dr. J V B Sankara Rao, Dr. T V Ramesh, Dr. Y.S Sarma, & Dr. Keerthi Priya Konkay. (2016). A case study report of denovo lymph node occurance of myeloid sarcoma. Pediatric Review: International Journal of Pediatric Research, 3(1), 73-76. https://doi.org/10.17511/ijpr.2016.i01.14
Section
Case Report