The value of urinary uric acid and creatinine ratio in neonatal asphyxia

  • Dr. Nikhil Gupta Junior Resident, Department of Pediatrics, Rohilkhand Medical College and Hospital, Bareilly, Uttar Pradesh, India
  • Dr. Alka Bhambri Professor and Head of Department, Department of Pediatrics, Rohilkhand Medical College and Hospital, Bareilly, Uttar Pradesh, India
  • Dr. Vedika A Bhat Assistant Professor, Department of Pediatrics, Rohilkhand Medical College and Hospital, Bareilly, Uttar Pradesh, India
  • Dr. Rashmi Katyal Associate Professor, Department of Community Medicine, Rohilkhand Medical College and Hospital, Bareilly, Uttar Pradesh, India
  • Dr. Shikha Saxena Assistant Professor, Department of Biochemistry, Rohilkhand Medical College and Hospital, Bareilly, Uttar Pradesh, India
  • Dr. Shashank Mishra Assistant Professor, Department of Pediatrics, Rohilkhand Medical College and Hospital, Bareilly, Uttar Pradesh, India
DOI: https://doi.org/10.17511/ijpr.2020.i08.06
Keywords: Uric acid, Creatinine, Neonatal asphyxia, Urinary uric acid

Abstract

Objective: The value of urinary uric acid and creatinine ratio in neonatal asphyxia.

Method: This was a prospective observational study conducted over one year, on 45 newborns admitted in NICU with perinatal asphyxia. Cord blood from the umbilical artery was sent for pH analysis and urinary uric acid and creatinine levels were estimated in spot urine samples.

Results: The urinary uric acid and creatinine ratio had a positive correlation with low APGAR scores at the 1st and 5th minute. Also, urinary uric acid to creatinine ratios was significantly higher in infants with severe HIE (3.180.61) when compared with infants of moderate HIE (2.190.32). It showed a significant negative correlation with pH of cord blood in neonates with perinatal asphyxia.

Conclusion: The urinary uric acid and creatinine ratio can be used as a supportive diagnostic test for early diagnosis of perinatal asphyxia.

Downloads

Download data is not yet available.

References

Costello A, Francis V, Byrne A, Puddephatt C. State of the World's Newborns: A Report from Saving Newborn Lives.2001;12(5):1-4

National Neonatal and Perinatal Database Report 2002-2003.1-58. Available at https://www.newbornwhocc.org/pdf/nnpd_report_2002-03.PDF.

Manzke H, Dörner K, Grünitz J. Urinary hypoxanthine, xanthine and uric acid excretion in new-born infants with perinatal complications. Acta Paediatric. 1977;66(6):713-717. doi: 10.1111/j.1651-2227.1977.tb07977.x.

Bhongir AV, Yakama AVV, Saha S, Radia SB, Pabbati J. The Urinary Uric Acid/Creatinine Ratio is An Adjuvant Marker for Perinatal Asphyxia. Europe J Pharmaceut Med Res. 2015;2(5):520-528.

Yashwanth K, Babu MS, Srinivas K, Mohan C, Aswani N, Rekha NA. A study of urinary uric acid to creatinine ratio in assessing the severity of birth asphyxia. IOSR J Dent Med Sci. 2017;16(10):69-76.

World Health Organization, working definitions neonatal and perinatal database South East Asia Regional; WHO, Geneva. 2006;1-7. Available at https://www.newbornwhocc.org/pdf/database.pdf.

Nelson KB, Ellenberg JH. American Academy of Pediatrics. The APGAR scores. Advances in Neonatal Care. 2006;6(4):220-223.

Krishnana E, Ponnusamy V, Sekar SP. Study of urinary uric acid and creatinine ratio as a marker of neonatal asphyxia for babies born in a tertiary care hospital. Int J Med Sci. 2017;5(12):5418-5423. doi: 10.18203/2320-6012.ijrms20175466.

Basu P, Som S, Choudhury N, Das H. Correlation between APGAR score and urinary uric acid to creatinine ratio in perinatal asphyxia. Indian J Clin Biochem. 2008;23(4):361-364. doi: 10.1007/s12291-008-0079-2.

CITATION
DOI: 10.17511/ijpr.2020.i08.06
Published: 2020-12-31
How to Cite
Dr. Nikhil Gupta, Dr. Alka Bhambri, Dr. Vedika A Bhat, Dr. Rashmi Katyal, Dr. Shikha Saxena, & Dr. Shashank Mishra. (2020). The value of urinary uric acid and creatinine ratio in neonatal asphyxia. Pediatric Review: International Journal of Pediatric Research, 7(8), 425-429. https://doi.org/10.17511/ijpr.2020.i08.06
Issue
Vol 7 No 8 (2020): Nov-Dec
Section
Original Article

Copyright (c) 2021 Author (s). Published by Siddharth Health Research and Social Welfare Society

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.