A cross sectional study of in-hospital cases of Pediatric Tuberculosis detected by CBNAAT at a tertiary care teaching hospital of Central India.
Background: Childhood tuberculosis is difficult in the identification of the organism due to improper sampling as well as low sensitivity of the smear. Newer diagnostic methods like Cartridge based nucleic acid amplification tests (CBNAAT) can rapidly identify Mycobacterium tuberculosis with improved sensitivity over the smear testing.
Material & Method: This observational record based cross-sectional study was undertaken to identify the epidemiology of tubercular infection in children diagnosed with CBNAAT. The study was carried out by analyzing the data of children from six months to 18 years who were diagnosed with Tuberculosis and treated with anti-tuberculosis therapy (ATT) from April 2018 to March 2020.
Results: Data of a total of 166 patients was analyzed. 42% of overall collected samples were reactive to CBNAAT testing for tuberculosis. 40 gastric aspirate samples were collected and only four (10%) turned reactive for tuberculosis by CBNAAT. None of the pediatric samples was positive for MDR TB. 66% of children completed treatment and 33% were declared cured.
Conclusion: 42% positivity after CBNAAT testing for tuberculosis infection in collected samples of sputum and gastric aspirate where only 10% yield in GA samples.
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