The early indicator of significant hyperbilirubinemia in healthy full-term infants at 72 hrs of age: A prospective cohort study

  • Sunil Arys Associate professor, Department of Pediatrics, M.G.M. Medical College, Indore, Madhya Prdaesh, India
  • Jyoti Prajapati Assistant professor, Department of Pediatrics, M.G.M. Medical College, Indore, Madhya Pradesh, India
  • Chetan Panwar Resident, Department of Pediatrics, M.G.M. Medical College, Indore, Madhya Pradesh, India
Keywords: Total serum bilirubin, Neonatal Hyperbilirubinemia, Risk factors, Significant hyperbilirubinemia, Full-term newborn


Introduction Hyperbilirubinaemia is a very common and frequently benign condition in newborns, but is a leading cause of hospitalisation in the first week of life. Many healthy full-term newborns develop significant hyperbilirubinemia, often leading to serious complications as bilirubin encephalopathy and death. The present study was aimed to determine early predators and risk factors in full-term healthy newborns developing significant hyperbilirubinemia.

Methods - This was a prospective observa-tional cohort study conducted at the department of pediatrics at a tertiary care teaching hospital over 1 year enrolling 200 full-term healthy newborns and following them from birth to 72 hrs of life to determine early predictors of hyperbilirubinemia. The data were analysed using the Statistical Package of Social Science Software (SPSS) program. Bilirubin levels measured at 72 hrs were compared to identify significant hyperbilirubinemia using cut off at or above high intermediate risk zone in Bhutani nom-ogram.

Results- Neonates with birth weight <2.5 kg, born through instrumental delivery, delayed feeding, dehydration, 24 Hr serum bilirubin >6mg/dl and 48 Hr serum bilirubin >11 mg/dl were significantly associated with significant hyperbilirubinemia( p<0.05)

Conclusion- These risk factors can be used as risk indicator to predict the development of significant hyperbiliru-binemia in such newborns and better pre-discharge counselling and followup can be ensured in such newborns especially in re-source-limited settings.


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DOI: 10.17511/ijpr.2021.i03.02
Published: 2021-06-30
How to Cite
Arys, S., Jyoti Prajapati, & Chetan Panwar. (2021). The early indicator of significant hyperbilirubinemia in healthy full-term infants at 72 hrs of age: A prospective cohort study. Pediatric Review: International Journal of Pediatric Research, 8(3), 130-136.
Original Article