To study umbilical cord blood TSH values in newborn in BHMRC over a period of 1 year
Abstract
Objectives: To study the association between umbilical cord blood TSH values and innate factors namely sex, birth, weight, gestational age. To study the effect of birth asphyxia on cord blood TSH. To estimate incidence of congenital hypothyroidism in newborns.
Methods: This study was carried out at Batra Hospital and Medical Research Centre, New Delhi from July 2008 to June 2009. Cord blood was collected immediately after birth and sent for TSH assay.
Result: In our study, we found no significant difference in cord blood TSH according to mode of delivery, pre-eclampsia, birth weight, male and female newborns. We found a significantly high mean cord blood TSH in newborn with APGAR < 7. One newborn was found to have congenital hypothyroidism.
Conclusion: This study helps to find out normative and mean values of cord blood TSH and to evaluate the effect of various perinatal factors on umbilical cord blood TSH.
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References
2. Pickering DE, Fisher DA: Therapeutic concept relating to hypothyroidism in childhood. J Chron Dis. J Chronic Dis. 1958 Mar;7(3):242-63. [PubMed]
3. Eayrs JT: Influence of the thyroid on the central nervous system, British Medical Bulletin. 1960 May;16:122-7.
4. P. Reed Larsen, Sidney H. Ingbar. The Thyroid Gland in: Wilson Foster Editor. Williams Text book of Endocrinology, 7th edition. Saunders: International edition: 447-448.
5. Smith DW, Blizzard RM, Wilkins L. The mental prognosis in hypothyroidism of infancy and childhood. A review of 128 cases. Pediatrics 1957 Jun;19(6):1011-22. [PubMed]
6. Klein AH, Meltzer S, Kenny FM. Improved prognosis in congenital hypothyroidism treated before age three months. J Pediatr. 1972 Nov;81(5):912-5.
7. Fisher DA, Dussault JH, Foley TP Jr. et al. Screening for congenital hypothyroidism: results of screening one million North American infants. J Pediatr.1979 May;94(5):700-5.
8. Newborn Committee of the European Thyroid Association. Neonatal screening for congenital hypothyroidism in Europe. Acta Endocrinol. suppl (copenh). 1979;223:3-29.
9. Feleke Y, Enquosellasie F, Deneke F, Abdulkadir J, Hawariat GW, Tilahun M, et al. Neonatal congenital hypothyroidism screening in Addis Ababa, Ethiopia. East Afrc Med J.2000;77(7):377-381. [PubMed]
10. Franklin RC, Carpenter LM, O'grady CM. Neonatal thyroid function: influence of perinatal factors. Arch Dis Child. 1985 feb;60(2):141-4. [PubMed]
11. Yalemtsehay Mekonnen, Gizachew W Hawariat, Bekele Chamiso, Friedhelm Raue. Thyroid stimulating hormone values from cord blood in neonates. Ethiop. J. Health Dev. 2003;17(2):125-130.
12. Rashmi, Seth A, Sekhri T, Agarwal A. Effect of perinatal factors on cord blood thyroid stimulating hormone levels. J Pediatr Endocrinol Metab. 2007 Jan;20(1):59-64. [PubMed]
13. Ward LS, Kunni IS, DE Barros Maciel RM. Thyroid stimulating hormone levels in cord blood are not influenced by non thyroidal mothers diseases. Sao Paulo Med J. 2000 Sep 7;118(5):114-7. [PubMed]
14. Khadilkar V, Khadilkar A, Cowasji H. Neonatal thyroid screening program using filter paper method. Cape News 2002;6:1.
15. Hardy JD, Azyed R, Doss I, Dhatt GS. Cord blood thyroxine and thyroid stimulating hormone screening for congenital hypothyroidism: how useful are they? J Pediatr Endocrinol Metab. 2008 Mar;21(3):245-9.
16. Lafranchi S, Hypothyroidism IN: Behrman RE, Kleigman RM, Jenson HB, editors. Nelson Textbook of Pediatrics, 18th ed. Philadelphia: Saunders. 2008:2316-2324.
17. Desai MP, Colaco MP, Ajgaokar AR, Mahadik CV, Rege C, Shiordkar VV et al. Neonatal screening for congenital hypothyroidism in a developing country: problems and strategies. Indian J Pediatr, 1987 jul-aug;54(4):571-81. [PubMed]
18. Manglik Arun Kumar, Chatterjee Nandita and Ghosh Gautam. Umbilical Cord Blood TSH Levels in Term Neonates: A Screening Tool for Congenital Hypothyroidism Indian Pediatrics. 2005;42:1029-1032. [PubMed]
Copyright (c) 2016 Author (s). Published by Siddharth Health Research and Social Welfare Society
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