Case report on congenital hypothyroidism: Early Vs Late Presentation
Keywords:
Hypothyroidism, Thyroid Dysgenesis, Ectopic Thyroid, Lingual Thyroid, Thyroid aplasia
Abstract
Most cases of congenital hypothyroidism are not hereditary and result from some form of thyroid dysgenesis. Thyroid dysgenesis can be aplasia, hypoplasia or an ectopic thyroid. Here we report two cases of thyroid dysgenesis presenting in different age groups.
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References
1. De Felice M, Di Lauro R. Thyroid development and its disorders: genetics and molecular mechanisms. Endocr Rev. 2004 Oct;25(5):722-46.
2. Pankaj Agrawal, Rajeev Philip, Sanjay Saran, Manish Gutch, Mohd Sayed Razi, Puspalata Agroiya, Keshavkumar Gupta3 Congenital hypothyroidism: Indian Journal of Endocrinology and Metabolism Review Article 2015; 19(2): 221-227 DOI: 10.4103/2230-8210.131748.
3. LaFranchi SH. Hypothyroidism. Pediatr Clin North Am. 1979 Feb;26(1):33-51.
4. Singhal P, Sharma KR, Singhal A. Lingual thyroid in children. J Indian Soc Pedod Prev Dent. 2011 Jul-Sep;29(3):270-2. doi: 10.4103/0970-4388.85840.
5. Col SS Anand, Dr. Vikas Sood, Lt Col PG Kumar, Air Cmde KM Suryanarayna ,Lt Col Narender Kotwal Lingual Thyroid: MJAFI. 2006; 62 (2) : 184-185 DOI: http://dx.doi.org/10.1016/S0377-1237(06)80068-7.
6. Ibrahim NA, Fadeyibi IO. Ectopic thyroid: etiology, pathology and management. Hormones (Athens). 2011 Oct-Dec;10(4):261-9.
7. Arancibia P, Veliz J, Barria M, Pineda G. Lingual thyroid: report of three cases. Thyroid. 1998 Nov;8(11):1055-7.
8. Williams JD, Sclafani AP, Slupchinskij O, Douge C. Evaluation and management of the lingual thyroid gland.Ann Otol Rhinol Laryngol. 1996 Apr;105(4):312-6.
9. Charles ND. Thyroid and whole-body imaging. In the thyroid, 5th ed. Ed Ingbar and Braveman. Lippincot, Philadelphia, 1986; 458-78.
10. Hari CK, Brown MJ, Thompson I. Tall cell variant of papillary carcinoma arising from ectopic thyroid tissue in the trachea. J Laryngol Otol. 1999 Feb;113(2):183-5.
11. Choi JY, Kim JH. A case of an ectopic thyroid gland at the lateral neck masquerading as a metastatic papillary thyroid carcinoma. J Korean Med Sci. 2008 Jun;23(3):548-50. doi: 10.3346/jkms.2008.23.3.548.
12. Aguirre A, de la Piedra M, Ruiz R, Portilla J. Ectopic thyroid tissue in the submandibular region. Oral Surg Oral Med Oral Pathol. 1991 Jan;71(1):73-6.
13. Salam MA. Ectopic thyroid mass adherent to the oesophagus. J Laryngol Otol. 1992 Aug;106(8):746-7.
14. Ozpolat B, Dogan OV, Gökaslan G, Erekul S, Yücel E. Ectopic thyroid gland on the ascending aorta with a partial pericardial defect: report of a case. Surg Today. 2007;37(6):486-8. Epub 2007 May 28.
15. Hagiuda J, Kuroda I, Tsukamoto T, Ueno M, Yokota C, Hirose T, Deguchi N. Ectopic thyroid in an adrenal mass: a case report. BMC Urol. 2006 Aug 10;6:18.
16. Eyüboğlu E, Kapan M, Ipek T, Ersan Y, Oz F. Ectopic thyroid in the abdomen: report of a case. Surg Today. 1999;29(5):472-4.
17. Liang K, Liu JF, Wang YH, Tang GC, Teng LH, Li F. Ectopic thyroid presenting as a gallbladder mass. Ann R Coll Surg Engl. 2010 May;92(4):W4-6. doi: 10.1308/147870810X12659688852473.
18. Amani Mel A, Benabadji N, Benzian Z, Amani S. Ectopic lingual thyroid. Indian J Nucl Med. 2012 Apr;27(2):124-6. doi: 10.4103/0972-3919.110718.
19. Rastogi MV, LaFranchi SH. Congenital hypothyroidism. Orphanet J Rare Dis. 2010 Jun 10;5:17. doi: 10.1186/1750-1172-5-17.
20. Brown RS, Bellisario RL, Mitchell E, Keating P, Botero D. Detection of thyrotropin binding inhibitory activity in neonatal blood spots. J Clin Endocrinol Metab. 1993 Oct;77(4):1005-8.
21. Pacaud D, Huot C, Gattereau A, Brown RS, Glorieux J, Dussault JH, Van Vliet G. Outcome in three siblings with antibody-mediated transient congenital hypothyroidism. JPediatr. 1995;127 (2):275–277. doi: 10.1016/S0022-3476(95)70308-X.
22. Vulsma T, Gons MH, de Vijlder JJ. Maternal-fetal transfer of thyroxine in congenital hypothyroidism due to a total organification defect or thyroid agenesis. N Engl J Med. 1989 Jul 6;321(1):13-6.
23. Grant DB, Smith I, Fuggle PW, Tokar S, Chapple J. Congenital hypothyroidism detected by neonatal screening: relationship between biochemical severity and early clinical features. ArchDisChild. 1992;67(1):87–90.
24. Ohnishi H, Sato H, Noda H, Inomata H, Sasaki N. Color Doppler ultrasonography: Diagnosis of ectopic thyroid gland in patients with congenital hypothyroidism caused by thyroid dysgenesis. J Clin Endocrinol Metab 2003;88:5145-9.
25. Selva KA, Mandel SH, Rien L, Sesser D, Miyahira R, Skeels M, Nelson JC, Lafranchi SH. Initial treatment dose of L-thyroxine in congenital hypothyroidism. J Pediatr. 2002 Dec;141(6):786-92.
26. American Academy of Pediatrics. Rose SR. Section on Endocrinology and Committee on Genetics ATABRPHC Lawson Wilkins Pediatric Endocrine Society. Foley T.Kaplowitz PB.Kaye CI.Sundararajan S.Varma SK. Update of newborn screening and therapy for congenital hypothyroidism. Pediatrics. 2006;117(6):2290–2303. doi: 10.1542/peds.2006-0915.
27. Talwar N, Mohan S, Ravi B, Andley M, Kumar A. Lithium-induced enlargement of a lingual thyroid. Singapore Med J. 2008 Mar;49(3):254-5.
2. Pankaj Agrawal, Rajeev Philip, Sanjay Saran, Manish Gutch, Mohd Sayed Razi, Puspalata Agroiya, Keshavkumar Gupta3 Congenital hypothyroidism: Indian Journal of Endocrinology and Metabolism Review Article 2015; 19(2): 221-227 DOI: 10.4103/2230-8210.131748.
3. LaFranchi SH. Hypothyroidism. Pediatr Clin North Am. 1979 Feb;26(1):33-51.
4. Singhal P, Sharma KR, Singhal A. Lingual thyroid in children. J Indian Soc Pedod Prev Dent. 2011 Jul-Sep;29(3):270-2. doi: 10.4103/0970-4388.85840.
5. Col SS Anand, Dr. Vikas Sood, Lt Col PG Kumar, Air Cmde KM Suryanarayna ,Lt Col Narender Kotwal Lingual Thyroid: MJAFI. 2006; 62 (2) : 184-185 DOI: http://dx.doi.org/10.1016/S0377-1237(06)80068-7.
6. Ibrahim NA, Fadeyibi IO. Ectopic thyroid: etiology, pathology and management. Hormones (Athens). 2011 Oct-Dec;10(4):261-9.
7. Arancibia P, Veliz J, Barria M, Pineda G. Lingual thyroid: report of three cases. Thyroid. 1998 Nov;8(11):1055-7.
8. Williams JD, Sclafani AP, Slupchinskij O, Douge C. Evaluation and management of the lingual thyroid gland.Ann Otol Rhinol Laryngol. 1996 Apr;105(4):312-6.
9. Charles ND. Thyroid and whole-body imaging. In the thyroid, 5th ed. Ed Ingbar and Braveman. Lippincot, Philadelphia, 1986; 458-78.
10. Hari CK, Brown MJ, Thompson I. Tall cell variant of papillary carcinoma arising from ectopic thyroid tissue in the trachea. J Laryngol Otol. 1999 Feb;113(2):183-5.
11. Choi JY, Kim JH. A case of an ectopic thyroid gland at the lateral neck masquerading as a metastatic papillary thyroid carcinoma. J Korean Med Sci. 2008 Jun;23(3):548-50. doi: 10.3346/jkms.2008.23.3.548.
12. Aguirre A, de la Piedra M, Ruiz R, Portilla J. Ectopic thyroid tissue in the submandibular region. Oral Surg Oral Med Oral Pathol. 1991 Jan;71(1):73-6.
13. Salam MA. Ectopic thyroid mass adherent to the oesophagus. J Laryngol Otol. 1992 Aug;106(8):746-7.
14. Ozpolat B, Dogan OV, Gökaslan G, Erekul S, Yücel E. Ectopic thyroid gland on the ascending aorta with a partial pericardial defect: report of a case. Surg Today. 2007;37(6):486-8. Epub 2007 May 28.
15. Hagiuda J, Kuroda I, Tsukamoto T, Ueno M, Yokota C, Hirose T, Deguchi N. Ectopic thyroid in an adrenal mass: a case report. BMC Urol. 2006 Aug 10;6:18.
16. Eyüboğlu E, Kapan M, Ipek T, Ersan Y, Oz F. Ectopic thyroid in the abdomen: report of a case. Surg Today. 1999;29(5):472-4.
17. Liang K, Liu JF, Wang YH, Tang GC, Teng LH, Li F. Ectopic thyroid presenting as a gallbladder mass. Ann R Coll Surg Engl. 2010 May;92(4):W4-6. doi: 10.1308/147870810X12659688852473.
18. Amani Mel A, Benabadji N, Benzian Z, Amani S. Ectopic lingual thyroid. Indian J Nucl Med. 2012 Apr;27(2):124-6. doi: 10.4103/0972-3919.110718.
19. Rastogi MV, LaFranchi SH. Congenital hypothyroidism. Orphanet J Rare Dis. 2010 Jun 10;5:17. doi: 10.1186/1750-1172-5-17.
20. Brown RS, Bellisario RL, Mitchell E, Keating P, Botero D. Detection of thyrotropin binding inhibitory activity in neonatal blood spots. J Clin Endocrinol Metab. 1993 Oct;77(4):1005-8.
21. Pacaud D, Huot C, Gattereau A, Brown RS, Glorieux J, Dussault JH, Van Vliet G. Outcome in three siblings with antibody-mediated transient congenital hypothyroidism. JPediatr. 1995;127 (2):275–277. doi: 10.1016/S0022-3476(95)70308-X.
22. Vulsma T, Gons MH, de Vijlder JJ. Maternal-fetal transfer of thyroxine in congenital hypothyroidism due to a total organification defect or thyroid agenesis. N Engl J Med. 1989 Jul 6;321(1):13-6.
23. Grant DB, Smith I, Fuggle PW, Tokar S, Chapple J. Congenital hypothyroidism detected by neonatal screening: relationship between biochemical severity and early clinical features. ArchDisChild. 1992;67(1):87–90.
24. Ohnishi H, Sato H, Noda H, Inomata H, Sasaki N. Color Doppler ultrasonography: Diagnosis of ectopic thyroid gland in patients with congenital hypothyroidism caused by thyroid dysgenesis. J Clin Endocrinol Metab 2003;88:5145-9.
25. Selva KA, Mandel SH, Rien L, Sesser D, Miyahira R, Skeels M, Nelson JC, Lafranchi SH. Initial treatment dose of L-thyroxine in congenital hypothyroidism. J Pediatr. 2002 Dec;141(6):786-92.
26. American Academy of Pediatrics. Rose SR. Section on Endocrinology and Committee on Genetics ATABRPHC Lawson Wilkins Pediatric Endocrine Society. Foley T.Kaplowitz PB.Kaye CI.Sundararajan S.Varma SK. Update of newborn screening and therapy for congenital hypothyroidism. Pediatrics. 2006;117(6):2290–2303. doi: 10.1542/peds.2006-0915.
27. Talwar N, Mohan S, Ravi B, Andley M, Kumar A. Lithium-induced enlargement of a lingual thyroid. Singapore Med J. 2008 Mar;49(3):254-5.
CITATION
DOI: 10.17511/ijpr.2016.i02.12
Published: 2016-02-29
How to Cite
Dr. Maya Menon, Dr. Sreejyothi. G, Dr. Deepa Binod, Dr. Raveendranath. K, & Dr. Riaz. I. (2016). Case report on congenital hypothyroidism: Early Vs Late Presentation. Pediatric Review: International Journal of Pediatric Research, 3(2), 135-139. https://doi.org/10.17511/ijpr.2016.i02.12
Section
Case Report
Copyright (c) 2016 Author (s). Published by Siddharth Health Research and Social Welfare Society
This work is licensed under a Creative Commons Attribution 4.0 International License.
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