Osteopenia of prematurity: Assessment of Biochemical parameters in Very low birth weight preterm neonates

  • Dr Sanjukta Mishra Kalinga Institute of Medical Sciences, Bhubaneswar, Odisha, India
  • Dr Sebaranjan Biswal Kalinga Institute of Medical Sciences, Bhubaneswar, Odisha, India
  • Dr Preetinanda Parida Kalinga Institute of Medical Sciences, Bhubaneswar, Odisha, India
DOI: https://doi.org/10.17511/ijpr.2016.i03.01
Keywords: Osteopenia, Very low birth weight, Alkaline phosphate, Metabolic bone disease

Abstract

Background: Osteopenia of prematurity, commonly called as metabolic bone disease (MBD), is mostly described in preterm babies (< 36weeks) with very low birth weight (VLBW). This condition is characterized by a reduction in bone mineral content (osteopenia), with or without rachitic changes, and is caused by several nutritional and biomechanical factors.

Objective: To determine the incidence of osteopenia of prematurity among high risk preterm VLBW babies and also to document changes in biochemical parameters including serum calcium, serum phosphate, serum alkaline phosphate (ALP) and serum creatinine in the above cases.

Material and method: This prospective observational study includes all the very low birth weight babies born fromNovember 2012 to July 2014. Present study comprised of 60 VLBW neonates of which 10 were <28weeks, 32 were 28-31week and 18 were 31-34weeks of gestation. Estimations of biochemical parameters were done at 2nd week of birth and again at 6th week to detect the incidence of osteopenia.

Result: There was a significant decrease inserum calcium and serum phosphorous level where asserum ALP documented a significant increase in preterm neonates when compared to control. 14 of 60 VLBW babies developed osteopenia of prematurity at 6th week of life.

Conclusion: As observed in the present study, gestational age, birth weight and ALP are considered to be significant risk factors and are associated with osteopenia. So early detection of this condition by monitoring of biochemical parameters in high-risk cases minimizes the development of osteopeniaand prevent future complications of osteopenia.

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Osteopenia of prematurity: Assessment of Biochemical parameters in Very low birth weight preterm neonates
CITATION
DOI: 10.17511/ijpr.2016.i03.01
Published: 2016-03-31
How to Cite
Dr Sanjukta Mishra, Dr Sebaranjan Biswal, & Dr Preetinanda Parida. (2016). Osteopenia of prematurity: Assessment of Biochemical parameters in Very low birth weight preterm neonates. Pediatric Review: International Journal of Pediatric Research, 3(3), 140-145. https://doi.org/10.17511/ijpr.2016.i03.01
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Vol 3 No 3 (2016): MARCH
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Original Article

Copyright (c) 2016 Author (s). Published by Siddharth Health Research and Social Welfare Society

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