Role of Inhaled Corticosteroids in Pediatric Asthma and Virus induced wheeze
Keywords:
Asthma ; Children ; Wheeze Nebulization; Pediatric; wheezing; Inhaled corticosteroids; Budesonide; Beclomethasone; Fluticasone; Asthma exacerbation; Asthma maintenance.
Abstract
Inhaled corticosteroids (ICS) are one of the important components of childhood asthma pharmacotherapy and a common first-line treatment. Treatment with ICS decreases asthma mortality and morbidity reduces symptoms, improves lung function, improves symptoms in childhood viral-induced wheezing and reduces the number of asthma exacerbations. This study reviews the role of ICS in childhood asthma, including their mechanism of action, clinical efficacy, safety profile, and adherence challenges. The benefits of ICS in controlling symptoms and reducing morbidity outweigh their potential risks when used appropriately in proper dosages. Strategies for optimizing ICS therapy and addressing concerns about long-term use are also discussed.
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14.Gotshall RW. Exercise-induced bronchoconstriction. Drugs. 2002;62:1725–39.
15. Szefler SJ, Leung DY. Glucocorticoid-resistant asthma: pathogenesis and clinical implications for management. Eur Respir J. 1997;10:1640–7.
16. Leung DY, Bloom JW. Update on glucocorticoid action and resistance. J Allergy Clin Immunol. 2003;111:3–22.
17.Spahn JD, Szefler SJ, Surs W, Doherty DE, Nimmagadda SR, Leung DY. A novel action of IL-13: induction of diminished monocyte glucocorticoid receptor-binding affinity. J Immunol. 1996;157:2654–9.
18.Buhl R. Local oropharyngeal side effects of inhaled corticosteroids in patients with asthma. Allergy. 2006;61:518-26.
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How to Cite
Singh, R. (2025). Role of Inhaled Corticosteroids in Pediatric Asthma and Virus induced wheeze. Pediatric Review: International Journal of Pediatric Research, 12(1), 5-12. Retrieved from https://pediatrics.medresearch.in/index.php/ijpr/article/view/787
Section
Review Article
Copyright (c) 2025 Author (s). Published by Siddharth Health Research and Social Welfare Society
This work is licensed under a Creative Commons Attribution 4.0 International License.
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