Incidence of early neonatal hyperbilirubinemia in ABO incompatibility and cord bilirubin as a predictor for phototherapy
Keywords:
Neonatal hyperbilirubinemia, Cord bilirubin, ABO incompatability, Phototherapy, Neonatal Jaundice
Abstract
Neonatal Hyperbilirubinemia is a common condition in neonates and the most common pathological cause leading to hyperbilirubinemia is Rh or ABO incompatibility. Although most newborns with jaundice are otherwise healthy, the greatest risk associated with indirect hyperbilirubinemia is the development of bilirubin induced neurologic dysfunction which typically occurs with higher indirect bilirubin levels.
Aim of the Study: This study was done to (1) Find out the incidence of early hyperbilirubinemia and need for phototherapy in babies born to O+ve mother and (2) Cord Bilirubin as a marker for early phototherapy in ABO blood group incompatibility.
Method : This was a prospective cohort study which included 50 consecutive term appropriate for gestational age babies with blood group either A or B born to O+ve mother as cases and another 50 consecutive term appropriate for gestationalage babies with O+ve blood group born to O+ve mother served as control.
Result: 88% of the babies in the case group required phototherapy for > 24 hours whereas in the control group only 55% required phototherapy for > 24 hrs. Based on statistical analysis, there was a probability that the newborns who needed early phototherapy had a cord bilirubin 2.05 or more.
Conclusion: It may be concluded that babies with ABO incompatibility needed early and prolonged treatment compared to controls. A cord bilirubin above 2.05 can predict the need for treatment.
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References
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2. Zeitoun A, Elhagrasy H, Abdelsatar D. Predictive value of umbilical cord blood bilirubin in neonatal hyperbilirubinemia. Egyptian Pediatric Association Gazette. 2013 Jan;61(1):23-30.doi:10.1016.
3. Ambalavanan N, Carlo.W.A. Jaundice and hyperbilirubinemia in the Newborn. In Kliegman RM, Behrman RE, Stanton BF, Schor NF, St Geme III JW, Nelson text book of Peadiatrics: 20th ed. New Delhi Elseviers, 2015:Chapter 102: P 871-872.
4. Murray N, Roberts I. Haemolytic disease of the newborn. Archives of Disease in Childhood – Fetal and Neonatal Edition. 2007;92(2): F83-F88. doi: 10.1136/adc. 2005. 076794. [PubMed]
5. Naveen g. Nadig; a. C. Basavaraj early predictors of pathological jaundice due to ABO hemolytic disease International Journal of Pharma & Bio Sciences;Jul-Sep2013, 4 (3) pB-125-130.
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9. Ip S, Chung M, Kulig J, O'Brien R, Sege R, Glicken S, Maisels MJ, Lau J American Academy of Pediatrics Subcommittee on Hyperbilirubinemia An evidence-based review of important issues concerning neonatal hyperbilirubinemia ,Pediatrics. 2004 Jul;114(1):130-53.
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14. Venkatamurthy M1, Murali S.M2, Mamatha S3 A comparison study: cord serum albumin is compared with cord serum bilirubin as a risk indicator in predicting neonatal jaundice Journal of Evolution of Medical and Dental Sciences 2014 April 3(15) Page : 4017-4022. DOI:10.14260/ jemds/2014/2393.
15. Amar. Taksande, Krishna. Vihekar, Manish, et al. Prediction of the development of neonatal hyperbilirubinemia by increased umbilical cord blood bilirubin ,Indmedica Current Pediatric Research 2005 sep 9(1) 5 – 9.
16. Ben wood, Phyllis Culley, Claudia Roginski, Jean Powell, And John Waterhouse Factors affecting neonatal jaundice Archives of Disease in Childhood, 1979, 54, 111-115. [PubMed]
17. G.K. Suresh, R.E. Clark Cost-effectiveness of strategies that are intended to prevent kernicterus in newborn infants Pediatrics,2004 october 114 (4) 917–924. [PubMed]1. Kalakheti BK, Singh R, Bhatta NK, Karki A, Baral N. Risk of neonatal hyperbilirubinemia in babies born to 'O' positive mothers: a prospective cohort study Kathmandu Univ Med J (KUMJ). 2009 Jan- Mar;7(25):11-5.
2. Zeitoun A, Elhagrasy H, Abdelsatar D. Predictive value of umbilical cord blood bilirubin in neonatal hyperbilirubinemia. Egyptian Pediatric Association Gazette. 2013 Jan;61(1):23-30.doi:10.1016.
3. Ambalavanan N, Carlo.W.A. Jaundice and hyperbilirubinemia in the Newborn. In Kliegman RM, Behrman RE, Stanton BF, Schor NF, St Geme III JW, Nelson text book of Peadiatrics: 20th ed. New Delhi Elseviers, 2015:Chapter 102: P 871-872.
4. Murray N, Roberts I. Haemolytic disease of the newborn. Archives of Disease in Childhood – Fetal and Neonatal Edition. 2007;92(2): F83-F88. doi: 10.1136/adc. 2005. 076794. [PubMed]
5. Naveen g. Nadig; a. C. Basavaraj early predictors of pathological jaundice due to ABO hemolytic disease International Journal of Pharma & Bio Sciences;Jul-Sep2013, 4 (3) pB-125-130.
6. Eder F.A,Manno SC.Alloimmune Hemolytic Disease of the Fetus and Newborn In Greer PJ,Foerster J,Lukens NJ,Rodgers MG,Paraskevas F,Glader B.Wintrobes Clinical Hematology 11 edn volume 1,Philadelphia :.Llippincott Williams and Wilkins,2004.chapter 36p 1185-1186.
7. Mentzer WC, Glader BE. Erythrocyte disorder in infancy. In Avery’s disease of the newborn. Taruseh HW, Ballard RD Eds. 7thEdn. Philadelphia, WB Saunders Co. 1998:1080-1111.
8. Vinod K. Bhutani, Lois Johnson, Emidio M. Sivieri Predictive Ability of a Predischarge Hour-specific Serum Bilirubin for Subsequent Significant Hyperbilirubinemia in Healthy Term and Near-term Newborns, Pediatrics 1999 Jan, 103 (1);6- 14.
9. Ip S, Chung M, Kulig J, O'Brien R, Sege R, Glicken S, Maisels MJ, Lau J American Academy of Pediatrics Subcommittee on Hyperbilirubinemia An evidence-based review of important issues concerning neonatal hyperbilirubinemia ,Pediatrics. 2004 Jul;114(1):130-53.
10. Perry BW, Doumas BT, Bayse DD, Butler T, Cohen A, Fellows W, Garber CC, Howell B, Koch T, Krishnamurthy S, Louderback A, McComb RB, Miller D, Miller RR, Rand RN, Schaffer R.A candidate reference method for determination of bilirubin in serum. Test for transferability. Clin Chem. 1983 Feb;29(2):297-301. [PubMed]
11. American Academy of Pediatrics Subcommittee on Hyperbilirubinemia Management of hyperbilirubinemia in the newborn infant 35 or more weeks of gestation,Pediatrics2004 Jul;114(1):297-316. [PubMed]
12. Vinod K. Bhutani Phototherapy to Prevent Severe Neonatal Hyperbilirubinemia in the Newborn Infant 35 or More Weeks of Gestation, Pediatrics 2011 September 128(4):1046-52 S DOI: 10.154.
13. Martin.R, Cloherty JP. Neonatal Hyberbilirubinemia. In cloherty J.P, Eichenwald E .C, Stark A.R. Manual of Neonatal Care.6 edn, Philadelphia: Lippincott Williams and Wilkins, 2008.chapter 18p210-211.
14. Venkatamurthy M1, Murali S.M2, Mamatha S3 A comparison study: cord serum albumin is compared with cord serum bilirubin as a risk indicator in predicting neonatal jaundice Journal of Evolution of Medical and Dental Sciences 2014 April 3(15) Page : 4017-4022. DOI:10.14260/ jemds/2014/2393.
15. Amar. Taksande, Krishna. Vihekar, Manish, et al. Prediction of the development of neonatal hyperbilirubinemia by increased umbilical cord blood bilirubin ,Indmedica Current Pediatric Research 2005 sep 9(1) 5 – 9.
16. Ben wood, Phyllis Culley, Claudia Roginski, Jean Powell, And John Waterhouse Factors affecting neonatal jaundice Archives of Disease in Childhood, 1979, 54, 111-115. [PubMed]
17. G.K. Suresh, R.E. Clark Cost-effectiveness of strategies that are intended to prevent kernicterus in newborn infants Pediatrics,2004 october 114 (4) 917–924. [PubMed]
2. Zeitoun A, Elhagrasy H, Abdelsatar D. Predictive value of umbilical cord blood bilirubin in neonatal hyperbilirubinemia. Egyptian Pediatric Association Gazette. 2013 Jan;61(1):23-30.doi:10.1016.
3. Ambalavanan N, Carlo.W.A. Jaundice and hyperbilirubinemia in the Newborn. In Kliegman RM, Behrman RE, Stanton BF, Schor NF, St Geme III JW, Nelson text book of Peadiatrics: 20th ed. New Delhi Elseviers, 2015:Chapter 102: P 871-872.
4. Murray N, Roberts I. Haemolytic disease of the newborn. Archives of Disease in Childhood – Fetal and Neonatal Edition. 2007;92(2): F83-F88. doi: 10.1136/adc. 2005. 076794. [PubMed]
5. Naveen g. Nadig; a. C. Basavaraj early predictors of pathological jaundice due to ABO hemolytic disease International Journal of Pharma & Bio Sciences;Jul-Sep2013, 4 (3) pB-125-130.
6. Eder F.A,Manno SC.Alloimmune Hemolytic Disease of the Fetus and Newborn In Greer PJ,Foerster J,Lukens NJ,Rodgers MG,Paraskevas F,Glader B.Wintrobes Clinical Hematology 11 edn volume 1,Philadelphia :.Llippincott Williams and Wilkins,2004.chapter 36p 1185-1186.
7. Mentzer WC, Glader BE. Erythrocyte disorder in infancy. In Avery’s disease of the newborn. Taruseh HW, Ballard RD Eds. 7thEdn. Philadelphia, WB Saunders Co. 1998:1080-1111.
8. Vinod K. Bhutani, Lois Johnson, Emidio M. Sivieri Predictive Ability of a Predischarge Hour-specific Serum Bilirubin for Subsequent Significant Hyperbilirubinemia in Healthy Term and Near-term Newborns, Pediatrics 1999 Jan, 103 (1);6- 14.
9. Ip S, Chung M, Kulig J, O'Brien R, Sege R, Glicken S, Maisels MJ, Lau J American Academy of Pediatrics Subcommittee on Hyperbilirubinemia An evidence-based review of important issues concerning neonatal hyperbilirubinemia ,Pediatrics. 2004 Jul;114(1):130-53.
10. Perry BW, Doumas BT, Bayse DD, Butler T, Cohen A, Fellows W, Garber CC, Howell B, Koch T, Krishnamurthy S, Louderback A, McComb RB, Miller D, Miller RR, Rand RN, Schaffer R.A candidate reference method for determination of bilirubin in serum. Test for transferability. Clin Chem. 1983 Feb;29(2):297-301. [PubMed]
11. American Academy of Pediatrics Subcommittee on Hyperbilirubinemia Management of hyperbilirubinemia in the newborn infant 35 or more weeks of gestation,Pediatrics2004 Jul;114(1):297-316. [PubMed]
12. Vinod K. Bhutani Phototherapy to Prevent Severe Neonatal Hyperbilirubinemia in the Newborn Infant 35 or More Weeks of Gestation, Pediatrics 2011 September 128(4):1046-52 S DOI: 10.154.
13. Martin.R, Cloherty JP. Neonatal Hyberbilirubinemia. In cloherty J.P, Eichenwald E .C, Stark A.R. Manual of Neonatal Care.6 edn, Philadelphia: Lippincott Williams and Wilkins, 2008.chapter 18p210-211.
14. Venkatamurthy M1, Murali S.M2, Mamatha S3 A comparison study: cord serum albumin is compared with cord serum bilirubin as a risk indicator in predicting neonatal jaundice Journal of Evolution of Medical and Dental Sciences 2014 April 3(15) Page : 4017-4022. DOI:10.14260/ jemds/2014/2393.
15. Amar. Taksande, Krishna. Vihekar, Manish, et al. Prediction of the development of neonatal hyperbilirubinemia by increased umbilical cord blood bilirubin ,Indmedica Current Pediatric Research 2005 sep 9(1) 5 – 9.
16. Ben wood, Phyllis Culley, Claudia Roginski, Jean Powell, And John Waterhouse Factors affecting neonatal jaundice Archives of Disease in Childhood, 1979, 54, 111-115. [PubMed]
17. G.K. Suresh, R.E. Clark Cost-effectiveness of strategies that are intended to prevent kernicterus in newborn infants Pediatrics,2004 october 114 (4) 917–924. [PubMed]1. Kalakheti BK, Singh R, Bhatta NK, Karki A, Baral N. Risk of neonatal hyperbilirubinemia in babies born to 'O' positive mothers: a prospective cohort study Kathmandu Univ Med J (KUMJ). 2009 Jan- Mar;7(25):11-5.
2. Zeitoun A, Elhagrasy H, Abdelsatar D. Predictive value of umbilical cord blood bilirubin in neonatal hyperbilirubinemia. Egyptian Pediatric Association Gazette. 2013 Jan;61(1):23-30.doi:10.1016.
3. Ambalavanan N, Carlo.W.A. Jaundice and hyperbilirubinemia in the Newborn. In Kliegman RM, Behrman RE, Stanton BF, Schor NF, St Geme III JW, Nelson text book of Peadiatrics: 20th ed. New Delhi Elseviers, 2015:Chapter 102: P 871-872.
4. Murray N, Roberts I. Haemolytic disease of the newborn. Archives of Disease in Childhood – Fetal and Neonatal Edition. 2007;92(2): F83-F88. doi: 10.1136/adc. 2005. 076794. [PubMed]
5. Naveen g. Nadig; a. C. Basavaraj early predictors of pathological jaundice due to ABO hemolytic disease International Journal of Pharma & Bio Sciences;Jul-Sep2013, 4 (3) pB-125-130.
6. Eder F.A,Manno SC.Alloimmune Hemolytic Disease of the Fetus and Newborn In Greer PJ,Foerster J,Lukens NJ,Rodgers MG,Paraskevas F,Glader B.Wintrobes Clinical Hematology 11 edn volume 1,Philadelphia :.Llippincott Williams and Wilkins,2004.chapter 36p 1185-1186.
7. Mentzer WC, Glader BE. Erythrocyte disorder in infancy. In Avery’s disease of the newborn. Taruseh HW, Ballard RD Eds. 7thEdn. Philadelphia, WB Saunders Co. 1998:1080-1111.
8. Vinod K. Bhutani, Lois Johnson, Emidio M. Sivieri Predictive Ability of a Predischarge Hour-specific Serum Bilirubin for Subsequent Significant Hyperbilirubinemia in Healthy Term and Near-term Newborns, Pediatrics 1999 Jan, 103 (1);6- 14.
9. Ip S, Chung M, Kulig J, O'Brien R, Sege R, Glicken S, Maisels MJ, Lau J American Academy of Pediatrics Subcommittee on Hyperbilirubinemia An evidence-based review of important issues concerning neonatal hyperbilirubinemia ,Pediatrics. 2004 Jul;114(1):130-53.
10. Perry BW, Doumas BT, Bayse DD, Butler T, Cohen A, Fellows W, Garber CC, Howell B, Koch T, Krishnamurthy S, Louderback A, McComb RB, Miller D, Miller RR, Rand RN, Schaffer R.A candidate reference method for determination of bilirubin in serum. Test for transferability. Clin Chem. 1983 Feb;29(2):297-301. [PubMed]
11. American Academy of Pediatrics Subcommittee on Hyperbilirubinemia Management of hyperbilirubinemia in the newborn infant 35 or more weeks of gestation,Pediatrics2004 Jul;114(1):297-316. [PubMed]
12. Vinod K. Bhutani Phototherapy to Prevent Severe Neonatal Hyperbilirubinemia in the Newborn Infant 35 or More Weeks of Gestation, Pediatrics 2011 September 128(4):1046-52 S DOI: 10.154.
13. Martin.R, Cloherty JP. Neonatal Hyberbilirubinemia. In cloherty J.P, Eichenwald E .C, Stark A.R. Manual of Neonatal Care.6 edn, Philadelphia: Lippincott Williams and Wilkins, 2008.chapter 18p210-211.
14. Venkatamurthy M1, Murali S.M2, Mamatha S3 A comparison study: cord serum albumin is compared with cord serum bilirubin as a risk indicator in predicting neonatal jaundice Journal of Evolution of Medical and Dental Sciences 2014 April 3(15) Page : 4017-4022. DOI:10.14260/ jemds/2014/2393.
15. Amar. Taksande, Krishna. Vihekar, Manish, et al. Prediction of the development of neonatal hyperbilirubinemia by increased umbilical cord blood bilirubin ,Indmedica Current Pediatric Research 2005 sep 9(1) 5 – 9.
16. Ben wood, Phyllis Culley, Claudia Roginski, Jean Powell, And John Waterhouse Factors affecting neonatal jaundice Archives of Disease in Childhood, 1979, 54, 111-115. [PubMed]
17. G.K. Suresh, R.E. Clark Cost-effectiveness of strategies that are intended to prevent kernicterus in newborn infants Pediatrics,2004 october 114 (4) 917–924. [PubMed]
CITATION
DOI: 10.17511/ijpr.2016.i04.03
Published: 2016-04-30
How to Cite
Dr. Maya Menon, Dr. Sreejyothi. G, & Dr. Raveendranath. K. (2016). Incidence of early neonatal hyperbilirubinemia in ABO incompatibility and cord bilirubin as a predictor for phototherapy. Pediatric Review: International Journal of Pediatric Research, 3(4), 221-227. https://doi.org/10.17511/ijpr.2016.i04.03
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